老年乳腺癌组织中雌激素受体、孕激素受体、人表皮生长因子受体2的表达及临床意义

Expressions of estrogen receptor,progesterone receptor and human epithelial receptor-2 in elderly breast cancer patients and their clinical significance

目的:分析雌激素受体(estrogen receptor,ER),孕激素受体(progesterone receptor,PR),人表皮生长因子受体2(human epithelial receptor-2,CerbB2)在老年女性乳腺癌中的表达情况,并探讨其临床意义。方法:回顾性分析125例老年乳腺癌患者的临床资料,免疫组织化学法检测ER,PR及CerbB2的表达情况,分析其与肿块大小、组织学分级、肿瘤部位以及淋巴结转移情况的关系。结果:ER,PR,CerbB2呈阳性表达者分别为84例(67.2%),83例(66.4%),25例(20.0%)。ER,PR阳性表达与患者组织学分级相关,CerbB2阳性表达与患者肿块大小、组织学分级和淋巴结转移显著相关(P均<0.01)。3年及5年生存率分别为74.9%和62.0%,中位生存时间6.9年。结论:ER,PR在老年乳腺癌患者中阳性表达率高,而CerbB2阳性表达率低,联合检测三者表达可较好地反映老年乳腺癌病理生物学特征并指导手术治疗。

Objective:To analyze the expressions of estrogen receptor(ER),progesterone receptor(PR) and human epithelial receptor-2(CerbB2) in elderly patients with breast cancer,and to investigate its clinical significance.Methods:One hundred and twenty-five female breast cancer patients aged 65years and older were enrolled in the study.Clinical data of all the patients were retrospectively reviewed.Expressions of ER,PR and CerbB2 were detected by immunohistochemistry.Correlation between expressions of ER,PR and CerbB2 and tumor size,histological grade,tumor location,lymph node metastasis were statistically analyzed.Results:The positive expressions of ER,PR and CerbB2 were 84(67.2%),83(66.4%) and 25(20.0%),respectively.The expressions of ER and PR were correlated with histological grade,while CerbB2 expression was correlated with histological grade,tumor size and lymph node metastasis,respectively(both P < 0.01).Three and five years overall survivals of elder patients were 74.9%and 62.0%;the mean overall survival was 6.9 years.Conclusions:The increased expressions of ER,PR and decreased expression of CerbB2 in female breast cancer patients reflected the pathobiological features of the cancer,which would be helpful for the treatment and surgical operation of breast neoplasms.