阴性或阳性症状为主的精神分裂症患者的P_(300)亚成份分析

Analysis on event-related potential P_(300) subcomponents in schizophrenia patients with positive or negative symptoms

目的探讨P300亚成份在以阴性或阳性症状为主的精神分裂症患者认知障碍评定中的价值。方法对56例以阴性症状为主的患者(阴性组)和49例以阳性症状为主的患者(阳性组)分别进行P3a及P3b检测,比较其与正常对照组的差异。结果阴性组在F Z点的平均P3a潜伏期较阳性组显著延长(P<0.01)、F Z和C Z点的平均P3a波幅及C Z和P Z点的平均P3b波幅显著低于阳性组与正常对照组(分别P<0.01和P<0.05)。结论以阴性症状为主的精神分裂症患者的认知功能损伤可能比以阳性症状为主者严重,新奇刺激P3a对于以阴性症状为主的患者的认知功能评估更有意义。

Objective To explore the value of event-related potential P300 subcomponents in the evaluation of cognitive function in schizophrenia patients mainly with positive or negative symptoms . Methods The P3a and P3b were tested in 56 schizophrenia patients mainly with negative symptoms ( the negative group ) and 49 schizophrenia patients mainly with positive symptom ( the positive group ) respectively , and the findings were compared with that from the control group. Results In negative group, the mean latency of P3a at FZ was obviously extended than that in the positive group (P<0.01), the mean amplitudes of P3a at FZ and CZ as well as the mean amplitudes of P3b at CZ and PZ were significantly lower than those from the positive group and the control group ( P<0.01, P<0.05, respectively ) . Conclusion Schizophrenia patients mainly with negative symptoms have more impaired cognitive functions than those patients mainly with positive symptoms and which could be sensitively evaluated by the P 3a assessment .