雌二醇屈螺酮对绝经早期妇女心血管危险因素的影响

The effects of Estradiol Drospirenone on cardiovascular risk factors in early postmenopausal women

目的对绝经早期妇女用雌二醇屈螺酮进行治疗,观察对心血管功能的影响。方法将42例绝经早期妇女分为两组。A组22例,每日服用雌二醇屈螺酮片1片,连续6个月;B组20例,每日碳酸钙D3片1片,连续6个月。用药前后测定体重指数(BMI)、绝经症状评分、缺血性心血管疾病(ICVD)10年发病危险度评估、踝肱指数(ABI)、空腹胰岛素、空腹血糖、总胆固醇、甘油三脂、高密度脂蛋白、低密度脂蛋白、雌二醇、总睾酮、抗凝血酶III。结果 A组治疗后绝经症状评分、ICVD评分降低,雌二醇升高,总睾酮下降,收缩压和总胆固醇下降,与治疗前相比有显著性差异(t=-13.432~8.015,P=0.000~0.042);B组治疗后绝经症状评分和ICVD评分升高,与治疗前相比有显著性差异(t=-4.158^-3.476,P=0.003~0.029)。其余各项指标两组用药前后没有明显改变。结论绝经早期妇女使用雌二醇屈螺酮,可以缓解绝经相关症状,减少ICVD评分,降低收缩压,同时使总睾酮和总胆固醇下降,对心血管系统具有保护作用。

Objective To observe the effects of Estradiol Drospirenone on cardiovascular function in early postmenopausal women. Methods The 42 early postmenopausal women were divided into two groups. In group A 22 cases were taken Estradiol Drospirenone a tablet once a day for 6 months.In group B 20 cases were taken Calcium D3 a tablet once a day for 6 months. BMI, Menopausal Symptom Score, ICVD, ABI, blood pressure, fasting insulin, fasting glucose, total cholesterol, triglycerides, HDL, LDL, estradiol, total testosterone, antithrombin III were evaluated before and after therapy. Results In group A Menopausal Symptom Scores and ICVD were lower, estradiol was elevated and total testosterone was declined, systolic blood pressures and total cholesterol were decreased after therapy. There was a significant difference compared with before treatment(t=-13.432~8.015, P=0.000~0.042). In group B menopausal Symptom Scores and ICVD were elevated after therapy. There was a significant difference compared with before treatment (t=-4.158^-3.476, P=0.003~0.029). There was no significant change on the other of the indicators before and after treatment in these two groups. Conclusions In early postmenopausal women, Estradiol Drospirenone may relief the related symptoms of the menopause, decline the ICVD scores, reduce systolic blood pressure, decrease total testosterone and total cholesterol. It has been shown that Estradiol Drospirenone can protect cardiovascular function.