小动物SPECT的应用和进展

The application and development of animal SPECT

小动物SPECT是实验科学向临床科学过渡的重要工具,已广泛应用在临床前新药研发、人类生理和疾病实验动物模型的研究中.随着硬件技术和图像重建算法的进展,小动物SPECT的系统灵敏度、空间分辨率和定量准确性都得到了明显提高.与小动物PET相比,小动物SPECT在研究的适应性、放射性药物来源的便利性及研究成本上具有更大优势,在一段时间内仍将是疾病临床前分子影像研究的重要手段之一.

Animal SPECT is an important research approach for translating preclinical to clinical study.It has been widely applied in drug development and the researches of physiology and diseases in small animal models.With the rapid progresses of hardware technology and algorithm of image reconstruction,the systemic sensitivity,spatial resolution and quantitative accuracy of animal SPECT have been greatly improved.Animal SPECT has great advantages over animal PET with the feasibility of study,the convenience acquisition of radiopharmaceuticals and relative low cost.In a certain period,animal SPECT will still be a main approach for preclinical researches of molecular imaging.