温阳通络胶囊合用腰八针温针灸对腰椎间盘突出症患者改良JOA评分、SOD和MDA的影响

The Influence of Wenyangtongluo Capsules Combined with Warm Needling of Eight Needles on Waist for Lumbar Disc Herniation on Modified JOA Scores, SOD and MDA

目的：观察温阳通络胶囊合用腰八针温针灸对腰椎间盘突出症患者JOA评分、SOD活性和MDA含量的影响。方法：将120例腰椎间盘突出症患者随机均分为治疗组（温阳通络胶囊配合腰八针温针灸合用组）、对照1组（温阳通络胶囊组）、对照2组（腰八针温针灸组）三组，连续治疗4周后采用改良JOA评分评价其临床疗效，并分别于治疗前后检查空腹血浆SOD、MDA。结果：治疗组临床疗效较对照1组和对照2组均有显著性改善（P<0.05）。治疗后三组血浆SOD活性均较治疗前显著性增高、MDA含量显著性降低（P<0.05），治疗组治疗后SOD活性较对照组1组和对照2组均有显著性增加（P<0.01），而MDA含量有显著性减少（P<0.01）。结论：温阳通络胶囊配合腰八针温针灸是治疗LDH的有效方法之一，可提高患者血浆SOD活性、降低MDA水平，LDH临床疗效好于温阳通络胶囊和腰八针温针灸的单独应用。

Objective:To observe the influence of Wenyangtongluo capsules combined with warm needling of eight needles on waist for lumbar disc herniation on modified JOA scores, SOD and MDA. Methods:120 patients were randomly divided into treatment group (Wenyangtongluo capsules combined with warm needling of eight needles on waist group), control group 1 (Wenyangtongluo capsules group) and control group 2 (warm nee-dling of eight needles on waist group), used modified JOA scores to evaluate the efficacy after continuous treating for 4 weeks, and checked the fast-ing plasma SOD and MDA before and after treatment. Results:Compared with control group1 and control group 2, the efficacy of treatment group had significantly improved (P<0.05). After treatment, the activity of plasma SOD had significantly increased and the content of MDA had significant-ly decreased (P<0.05);compared with control group1 and control group 2, the activity of SOD of treatment group that after the treatment had signifi-cantly increased (P<0.01) and MDA had significantly decreased (P<0.01). Conclusion:Wenyangtongluo capsules combined with warm needling of eight needles on waist is one of the effective ways to treat lumbar disc herniation, it can improve the activity of plasma SOD and reduce the level of MDA, and the efficacy is better than separately using Wenyangtongluo capsules or warm needling of eight needles on waist.