期刊文献+

阿司匹林对高血压患者血清hs-CRP的影响 被引量:1

下载PDF
导出
摘要 目的探讨阿司匹林对高血压患者血清高敏C反应蛋白(hs-CRP)的影响及意义。方法 65例高血压患者随机分为观察组35例及对照组30例。两组均口服盐酸贝那普利2.5 mg,1次/d;观察组在此基础上加用阿司匹林100 mg,1次/d。治疗前和治疗1个月后常规采血分离血清,采用比浊法检测血清hs-CRP水平。结果观察组及对照组治疗前血清hs-CRP水平无显著差异;治疗后分别为(8.46±0.87)mg/L、(9.89±1.64)mg/L,P<0.05。结论阿司匹林可降低高血压患者血清hs-CRP水平。
出处 《山东医药》 CAS 2013年第30期34-35,共2页 Shandong Medical Journal
  • 相关文献

参考文献10

  • 1Libby P,Ridker PM. Inflammation and atherosclerosis:role of C-reactive protein in risk assessment[J].American Journal of Medicine,2004,(Suppl6):9-16.
  • 2Erden M,Kocaman SA,Poyraz F. Incremental effects of serum uricacid levels,autonomic dysfunction,and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals[J].Turk Kardiyol Dern Ars,2011,(07):531-539.
  • 3Mauno V,Hannu K,Esko K. Proinflammation and hypertension:a population-based study[J].Mediators of Inflammation,2008,(04):619-704.
  • 4Salles GF,Fiszman R,Cardoso CR. Relation of left ventricular hypertrophy with systemic inflammation and endothelial damage in resistant hypertension[J].Hypertension,2007,(04):723-728.doi:10.1161/HYPERTENSIONAHA.107.093120.
  • 5Mattace-Raso FU,Verwoert GC,Hofman A. Inflammation and incident-isolated systolic hypertension in older adults:the Rotterdam study[J].Journal of Hypertension,2010,(05):892-895.
  • 6Mateos-Cáceres PJ,Zamorano-León J J,Rodríguez-Sierra P. New and old mechanisms associated with hypertension in the elderly[J].Int J Hypertens,2012,(01):150107.
  • 7陈宝峰,徐新,范文茂,肖雨雄,何凤屏,马绍椿,唐良秋,章蓓蓓.原发性高血压患者血清白细胞介素-18水平与颈动脉内膜中层厚度的相关性[J].广东医学,2007,28(9):1450-1453. 被引量:5
  • 8Xu T,Ju Z,Tong W. Relation ship of C-reactive protein with hypertension and interactions between inereased C-reactive protein and other risk factors on hypertension in Mongolian people,China[J].Circulation,2008,(08):1324-1328.
  • 9Perticone F,Maio R,Sciacqua A. Endothelial dysfunction and CRP are risk factors for diabetes in essential hypertension[J].Diabetes,2008,(01):167-171.doi:10.2337/db07-1189.
  • 10Bickel C,Rupprecht HJ,Blankenberg S. Relation of inflammation and statin thera-py to long-term mortality in patients with angiographically proven coronary artery disease[J].American Journal of Cardiology,2002,(08):901-908.

二级参考文献11

  • 1许金成,王淑斐,刘华锋,袁岩,洪玉芬.高血压病患者血浆白细胞介素18水平的检测与分析[J].广东医学院学报,2004,22(4):331-332. 被引量:7
  • 2无,龚兰生,许玉韵,张维忠,刘望彭,王新房,王宏宇,张瑞岩,郭远,李运田,马志敏,芦娜,倪永斌,王敏,杨娅,何建国,高旭光,丁康,沈晨阳,陈生龙,史旭波,陶军.中国血管病变早期检测技术应用指南(第一次报告)[J].中国民康医学,2006,18(9):323-331. 被引量:94
  • 3ROSS R.Cell biology of atherosclerosis[J].Ann Rev Physiol,1995,57:791 -795.
  • 4WHITMAN S C,RAVISANKAR P,DAUGHERTY A.Interleukin -18 enhances atherosclerosis in apolipoprotein E (-/-) mice through release of interferon-gamma[J].Circ Res,2002,90(2):E34 -E38.
  • 5MALLAT Z,CORBAZ A,SCOAZEC A,et al.Interleukin-18/interleukin -18 binding protein signaling modulates atherosclerotic lesion development and stability[J].Circ Res,2001,89 (7):E41-E45.
  • 6KAWASAKI D,TSUJINO T,MORIMOTO S,et al.Usefulness of circulating interleukin-18 concentration in acute myocardial infaretion as a risk factor for late restenosis after emergency coronary angioplasty[J].Am J Cardilo,2003,91 (10):1 258-1 261.
  • 7ELHAGE R,JAWIEN J,RUDLING M,et al.Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice[J].Cardiovasc Res,2003,59(1):234 -240.
  • 8YAMAGAMI H,KITAGAWA K,HOSHI T,et al.Associations of serum IL-18 levels with carotid intima -media thickness[J].Arterioscler Thromb Vasc Biol,2005,25(7):1 458 -1 462.
  • 9LEU H B,CHEN J W,WU T C,et al.Effects of fluvastatin,an HMG-CoA reductase inhibitor,on serum levels of interleukin-18 and matrix metalloproteinase -9 in patients with hypercholesterolemia[J].Clin Cardiol,2005,28(9):423 -428.
  • 10黎镇垣,马中富,甄慰菽,刘秀琴,肖阳,郭恢元,刘剑辉,黄清衡.动态观察高血压患者血清白细胞介素18改变的临床意义[J].标记免疫分析与临床,2003,10(1):1-3. 被引量:12

共引文献4

同被引文献13

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部