脑苷肌肽及丹参注射液联合治疗新生儿缺氧缺血性脑病的临床观察

Clinical observation of cattle encephalon glycoside and ignotin injection combined with Danshen injection on neonatal hypoxic-ischemic encephalopathy

目的研究分析脑苷肌肽联合丹参注射液在新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopahy,HIE)临床治疗中的应用价值。方法选取2013年1月~2014年1月武警北京市总队第三医院收治的60例HIE患儿并随机分成研究组(n=30)及对照组(n=30)。对照组采用常规治疗,研究组则在常规治疗的基础上给予脑苷肌肽及丹参注射液联合治疗。比较2组患儿临床症状的改善情况与临床治疗效果。结果治疗10 d后,研究组总有效率显著高于对照组(P<0.05);与对照组比较,研究组的反射恢复时间、意识恢复时间、肌张力恢复时间均显著缩短(P<0.05);研究组的新生儿行为神经测定(neonatal behavioral neurological assessment,NBNA)评分显著高于对照组(P<0.05);研究组及对照组患儿的器官功能发生损伤与并发症情况比较差异具有统计学意义(P<0.05)。结论脑苷肌肽联合丹参注射液治疗HIE具有安全有效,不良反应少等特点。

Objective To study the clinical value of cattle encephalon glycoside and ignotin injection combined with Danshen injection in the treatment of neonatal hypoxic-ischemic encephalopathy( HIE). Methods From Jan. 2013 to Jan. 2014,60 cases of neonatal HIE were selected in the Third Hospital of Beijing Armed Police Corps and randomly divided into study group(n = 30) and control group(n = 30). The control group were given conventional treatment,and the study group were treated with cattle encephalon glycoside and ignotin injection combined with Danshen injection on the basis of conventional therapy. The clinical symptoms and effects in two groups were compared. Results After 10 days treatment,the total effective rate of study group was significantly higher than that of control group(P < 0. 05); compared with control group,the recovery time of reflex,consciousness and muscle tension in study group shortened significantly( P < 0. 05);the neonatal behavioral neurological assessment( NBNA) score in study group was higher than that in control group(P < 0. 05); compare organ damage and complications in two groups,there were significant differences( P < 0. 05).Conclusion It is safe,effective and has less adverse reactions that cattle encephalon glycoside and ignotin injection combined with Danshen injection in the treatment of neonatal hypoxic ischemic encephalopathy.