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胰岛β细胞功能受损是2型糖尿病致病的关键因素:遗传学研究进展的启示 被引量：3

Impaired islet β cell function as a critical cause of type 2 diabetes: what could we learn from genetic studies
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摘要 胰岛β细胞功能受损和胰岛素抵抗是2型糖尿病致病的两个关键因素.但是何种因素更为重要尚有争议.
作者 胡仁明 杨震
机构地区 复旦大学附属华山医院内分泌代谢科复旦大学内分泌糖尿病研究所
出处 《中华糖尿病杂志》 CAS 2009年第2期-,共3页 CHINESE JOURNAL OF DIABETES MELLITUS
分类号 R587.1 [医药卫生—内分泌]
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参考文献13

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  • 2胡仁明;朱禧星.糖尿病的病因、分类和诊断[A]北京:人民卫生出版社,20051015-1026.
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二级参考文献12

  • 1方启晨,张蓉,王从容,林辛,项坤三.中国人早发及多发糖尿病家系HNF-1α基因突变的筛查[J].中华医学遗传学杂志,2004,21(4):329-334. 被引量：9
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共引文献1

同被引文献40

  • 1Mbanya JC, Pani LN, Mbanya DN, et al. Reduced insulin secretion in offspring of African type 2diabeteic parent. Diabetes Care 2000 ;23 : 1761 - 1765.
  • 2Matsumoto K, Sakamaki H, Izumino K, et al. Increased in- sulin sensitivity and decreased insulin secretion in offspring of insulin sensitive type 2 diabetic patients. Metabolism 2000 ; 49 : 1219 - 1223.
  • 3Doria A, Patti ME, Kahn CR. The emerging genetic archi- tecture of type 2 diabetes. Cell Metab 2008 ;8 : 186 - 200.
  • 4Kulkami RN, Jhala US, Winnay JN, et al. PDX1 haploin sufficiency limits the compensatory islet hyperplasia that occurs in re- sponse to insulin resistance. J Clin Invest 2004;14(6) :828 -836.
  • 5Bachar E, Ariav Y, Ketzinel-gilad M, et al. Glucose ampli- fies fatty acid-induced endoplasmic reticulum stress in pancreatic beta- cells via activation of mTORC1 . PLoS One 2009 ;4 (3) :e4954.
  • 6Giacca A, Xiao C T, Oprescu A I, et al. Lipid-induced pan- creatic β-cell dysfunction:focus on vivo studies. J. American Journal of Physiology - Endocrinology and Metabolism. Published 1 February 2011 ;300 : E255 - E262.
  • 7Hebda JA, Miranker AD. The interplay of catalysis and toxici- ty by amyloid intermediates on lipid bilayers: insights from type II dia- betes. Annu Rev Biophys 2009 ;38 : 125.152.
  • 8Shigihara N, Fukunaka A, Hara A, et al. Human IAPP-in- duced pancreatic β cell toxicity and its regulation by autophagy. J Clin Invest 2014;124(8) :3634 -3644.
  • 9Goldberg RB. Cytokine and cytokineqike inflammation mark- ers, endothelial dysfunction and imbalanced coagulation in develop- ment of diabetes and its complications. J Clin Endocrinal Metab 2009,9. Epub ahead of print.
  • 10Adaikalakoteswa riA, RemaM, Mohan V,et al. Oxidative DNA damage and augmentation of poly( ADP - ribose ) polymerase/ nuclear facto r- kappa B signaling in patients with type 2 diabetes and micro angiopa thy. Int J Biochemistry Cell Biol 2007; 39 (9): 1673 - 1684.

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二级引证文献9

中华糖尿病杂志
2009年 第2期

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