从青少年起病的成人型糖尿病基因看多基因糖尿病易感性
Common variants of MODY genes and polygenic forms of diabetes
摘要
近年研究表明,单基因糖尿病致病基因的高频多态位点可能影响多基因糖尿病的遗传易感性.这些高频多态本身对基因表达或活性的影响比较微弱甚至并不明显,但可增加个体的糖尿病患病风险.
出处
《中华糖尿病杂志》
CAS
2009年第6期-,共4页
CHINESE JOURNAL OF DIABETES MELLITUS
基金
国家自然科学基金,上海市青年科技启明星计划,上海市重点实验室建设项目
参考文献27
-
1Silander K,Mohlke KL,Scott LJ. Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes[J].Diabetes,2004,(4):1141-1149.doi:10.2337/diabetes.53.4.1141.
-
2Love-Gregory LD,Wasson J,Ma J. A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi Jewish population[J].Diabetes,2004,(4):1134-1140.doi:10.2337/diabetes.53.4.1134.
-
3Johansson S,Raeder H,Eide SA. Studies in 3523 Norwegians and meta-analysis in 11 571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians[J].Diabetes,2007,(12):3112-3117.doi:10.2337/db07-0513.
-
4Lehman DM,Richardson DK,Jenkinson CP. P2 promoter variants of the hepatocyte nuclear factor 4alpha genre are associated with type 2 diabetes in Mexican Americans[J].Diabetes,2007,(2):513-517.doi:10.2337/db06-0881.
-
5Hara K,Horikoshi M,Kitazato H. Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population[J].Diabetes,2006,(5):1260-1264.doi:10.2337/db05-0620.
-
6Andrulionyte L,Laukkanen O,Chiasson JL. Single nucleotide polymorphisma of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus:the STOP-NIDDM trial[J].Journal of Molecular Medicine,2006.701-708.doi:10.1007/s00109-006-0063-3.
-
7Holmkvist J,Almgren P,Lyssenko V. Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes[J].Diabetes,2008,(6):1738-1744.doi:10.2337/db06-1464.
-
8Hansen SK,Rose CS,Glumer C. Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population[J].Diabetalogia,2005,(3):452-458.doi:10.1007/s00125-005-1671-0.
-
9Damcott CM,Hoppman N,Ott SH. Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish[J].Diabetes,2004,(12):3337-3341.doi:10.2337/diabetes.53.12.3337.
-
10Shaat N,Karlsson E,Lernmark A. Common variants in MODY genes increase the risk of gestational diabetes mellitus[J].Diabetologia,2006.1545-1551.
-
1张谦,魏岱林,亓丽棠.糖尿病肾病的防治措施及护理对策[J].中国社区医师(医学专业),2004,6(22):77-78.
-
2肖新华,王姮.糖尿病基因治疗的研究[J].中华内分泌代谢杂志,1995,11(4):231-234. 被引量:1
-
3刘海霞,苏本利.糖尿病基因治疗的研究现状[J].中国全科医学(医生读者版),2010(2):41-42.
-
4糖尿病基因治疗研究有重要进展[J].吉林医学信息,1997,14(8):3-3.
-
5翁建平.关于1型糖尿病的诊断及患者数量的思考[J].中华糖尿病杂志,2013,5(7):385-388. 被引量:4
-
6张克勤.功能低减性内分泌疾病基因治疗进展[J].国外医学(内科学分册),1996,23(6):245-247.
-
7糖尿病基因新疗法[J].民间传奇故事,2003,0(6):50-50.
-
8郭振奎,陈刚,晏辉,王天成,栾萌.青少年起病的成人型糖尿病一家系八例[J].中华医学遗传学杂志,2006,23(4):483-483. 被引量:5
-
9吴文君,邹大进.糖尿病基因治疗的研究进展[J].中国临床康复,2003,7(24):3356-3357. 被引量:4
-
10陈星,张源潮.儿童混合性结缔组织病[J].中国实用儿科杂志,2007,22(6):470-473. 被引量:1