JAB1在胃癌组织中的表达及临床意义

Expression of JAB1 and its clinical significance in gastric carcinom

目的通过检测胃癌组织及相应癌旁组织中的C-JUN激活域结合蛋白(C-JUN activation domain binding protein,JAB1)的表达,探讨JAB1在胃癌的表达与临床病理参数及预后的关系。方法应用免疫组织化学方法(SP法)检测60例胃癌及相应癌旁组织中JAB1的表达情况,并分析其表达与胃癌分化程度、临床分期、淋巴结转移等临床病理参数及预后的关系。结果 JAB1在胃癌组织的阳性表达率为71.7%(43/60),癌旁组织的阳性表达率为23.3%(14/60),两者比较差异有统计学意义(χ2=28.104,P<0.001)。JAB1蛋白在胃癌组织的表达与组织分化程度、浸润深度和淋巴转移显著有关(P<0.05),与患者性别、年龄、肿瘤大小、大体分型、远处转移无关(P>0.05)。癌组织JAB1阳性表达患者5年生存率为43.4%,显著低于阴性患者的64.7%(P<0.05)。结论 JAB1在胃癌组织中高表达,其表达与胃癌分化程度、浸润及淋巴转移及预后相关,参与胃癌的发生、发展,有望成为胃癌诊治的新靶点。

Objective To investigate JAB1expression and its clinical role in gastric cancer.Methods The expression of C-JUN activation domain bingding protein1(JAB1) was examined in tumor tissues and paratumor tissues from 60 gastric cancer patients by immunohistochemical SP technique. The relationships between JAB1 expression and clinocopathological features and survival were analyzed. Results The positive expression rate of JAB1 in gastric cancer was 71.7%(43 / 60), significantly higher than 23.3%in the paratumor tissues(χ2=28.104,P <0.001). The expression of JAB1 protein was correlated with differentiation degree, infiltrative depth and lymphatic metastasis(P<0.05), but not with sex, age, tumor size, gross classifications and distant metastasis(P>0.05). The 5-year survival rate of the patients with positive JAB1 expression was 43.4%, significantly lower than 64.7% of those with negative JAB1 expression(P <0.05). Conclusions JAB1 is highly expressed in gastric cancer, and correlated with tumor differentiation, infiltration, lymph metastasis and prognosis.It is expected that JAB1 may be a new target for diagnosis and treatment of gastric cancer.