利培酮治疗家族性与散发性首发精神分裂症对照研究

A controlled study of risperidone in familial and sporadic schizophrenia.

目的 探讨利培酮治疗家族性与散发性精神分裂症的临床疗效。方法 依据有无精神病家族史分组 ,随机抽取有家族史的首发精神分裂症患者 36例 ,取同期无精神病家族史的精神分裂症患者 34例为对照。两组均应用利培酮治疗 3mo ,采用BPRS、SANS评定疗效 ,TESS评定副反应。结果 利培酮对家族性和散发性精神分裂症的阳性和阴性症状均有显著疗效。散发性患者起效更快、疗效更好。两组主要副反应发生率无显著差异。

Objective To investigate the curative effects and side effects of risperidone between familial and sporadic schizophrenia.Methods thirty six schizophrenic patients with positive family history were compared with thirty four schizophrenic patients with negative family history. They were both treated with risperidone for three months. The BPRS.SANS and TESS were used to evaluate the curative effects and side effects correspondingly. Results risperdone has an obviousiy curative effect in familial and sporadic schizophrenia. The sporadic schizophrenia is treated with risperidone more efficient than the faimilial schizophrenia Conclusion It is suggested that risperdone is more efficient in fammilial schizophrenia than sporadic schizophrenia.