电针与阿米替林治疗抑郁症对照研究

A controlled study of electro-acupuncture and amitriptyline in the treatment of depression

目的 探讨电针治疗抑郁症的疗效及安全性。方法 将 6 8例抑郁症患者随机分为观察组 (电针合并安慰剂治疗组 )34例 ,对照组 (阿米替林治疗组 ) 34例。观察组采用智能电针仪的抗抑郁波型 ,以毫针针刺百会、印堂穴 ,强度 2～ 3V ,2 0min·每次·Bid·d-1,10次·w-1,同时服用安慰剂 ;对照组给予阿米替林 5 0mg～ 2 5 0mg·d-1;两组疗程均为 6w。于治疗前及治疗后2、4、6w末评定HAMD、TESS、CGI。结果治疗 2、4、6w末两组患者HAMD总分与治疗前比较均有极显著性差异 (P <0 .0 1) ,两组间比较差异无显著性 (P >0 .0 5 ) ;治疗 2、4、6w末两组CGI评分与治疗前比较均有显著性差异 (P <0 .0 5 ) ,两组间比较差异无显著性 (P >0 .0 5 ) ;两组治疗前后TESS评分比较 ,观察组各因子分及总分明显高于观察组 ,差异有极显著性 (P <0 .0 1) ;治疗 6w末 ,两组HAMD评分无显著性差异 (P >0 .0 5 )。结论 电针与阿米替林治疗抑郁症疗效相当 。

Objective To explore the curative effect and safety of electro-acupuncture (EA) in the treatment of depression. Methods 68 patients with major depression were randomly divided into research group(n=34,treated with electroacupuacture and placebo) and control group(n=34,with amitriptyline). The research group was given acupuncture at Baihui and Yintang points by 2-3V, 20min/ time ,b.i.d., ten times/ week and combined with placebo; control group given amitriptyline 50-250mg /day for 6 weeks. Assessments were conducted by HAMD,TESS and CGI before and at the ends of 2nd, 4th and 6th week of treatment. Results At the ends of the 2nd,4th and 6th week, the total scores of HAMD and scores of CGI of both the 2 groups were significant difference from that of pre-treatment(P<0.01, P<0.05) and there was no significant difference between the 2 groups(both P>0.05);comparison of TESS between the 2 groups showed that all factors′scores and total score significantly higher in research group than in control group(P<0.01); at the end of 6th week, there was no significant difference in scores of HAMD(P>0.05). Conclusion The curative effect of EA is similar to that of amitriptyline in depression and has fewer side effects.