摘要
2006296 The effects of ammonium perchlorate (AP) on pulmonary fibrosis. SONG Ming-fen, et al. Wenzhou Med Coll, Wenzhou 325035. Chin J Emerg Med 2006;15(5):402-405. Objective:To explore the effects of AP on pulmonary fibrosis. Methods:Alveolar macrophages (AM) were treated by AP for 24 hours. Pulmonary fibroblasts (FB) were cultured with the supernatant of AM medium. The protein of transforming growth factor beta 1 (TGF-β1) of AM, the proliferative activity and hydroxyproline (Hyp) content of FB were examined. Rats were treated with AP by intratracheal instillation and sacrificed at 3 days. The TGF-β1 mRNA content in the lung was examined. Results:The positive staining macrophages in low and high AP groups and the quantity of TGF-β1 in high AP group were obviously higher than those in the control group (P<0.01 ). But there was no significant difference in the proliferative activity and Hyp content of FB in all groups.
2006296 The effects of ammonium perchlorate (AP) on pulmonary fibrosis. SONG Ming-fen, et al. Wenzhou Med Coll, Wenzhou 325035. Chin J Emerg Med 2006;15(5):402-405. Objective:To explore the effects of AP on pulmonary fibrosis. Methods:Alveolar macrophages (AM) were treated by AP for 24 hours. Pulmonary fibroblasts (FB) were cultured with the supernatant of AM medium. The protein of transforming growth factor beta 1 (TGF-β1) of AM, the proliferative activity and hydroxyproline (Hyp) content of FB were examined. Rats were treated with AP by intratracheal instillation and sacrificed at 3 days. The TGF-β1 mRNA content in the lung was examined. Results:The positive staining macrophages in low and high AP groups and the quantity of TGF-β1 in high AP group were obviously higher than those in the control group (P<0.01 ). But there was no significant difference in the proliferative activity and Hyp content of FB in all groups.
