摘要
8.1 Diabetes mellitus 2006324 Effect of vitamin C on blood lipid and the aorta expression of heparin sulfate proteoglycan protein in streptozotocin-induced diabetic rats. LI Qiang-xiang , et al. The 1st Affiliated Hosp, Nanhua Univ, Henyang 421001. Loudi 417000. Chin J Atrero scler 2006;14(3):197-200. Objective: To observe the effect of vitamin C on blood lipid and aorta expression of heparin sulfate proteoglycan protein (HSPG) in streptozotocin-induced diabetic rats. Methods:Diabetic nephropathy rats were induced by intraperitoneal injection of STZ. Rats were allocated to normal control group, model group, and vitamin C group for 16 weeks. During and after the treatment, during and after the treatment, Its general state, blood suger ( BS), triglyceride (TG), total cholesterol (TC), low density lipoprotein ( LDLC), high density lipoprotein (HDLC), glycosylated hemoglobin (HbAlc) and glycosylated low density lipoprotein (G-LDL) Alteration of tissue morphology via HE staining was observed after the aorta was taken out from the rats executed by narcosis; heparin sulfate proteoglyean protein, were determined by immunohistochemistry. Results: (1) Diabetes mellitus and aorta lesion occurred in the four model groups. (2)Vitamin C had no effect on the blood gloucose levels, while they could improve the general state, improve the general state, decrease triglyceride (P<0.05), serum cholesterol (P<0.05), low density lipoprotein (P<0.05), glycosylated hemoglobin (P<0.05), and glycated low density lipoprotein (P<0.05), increase high density lipoprotein (P<0.05), The expression of HSPG in the kidney were significantly inhibited (P<0.05) at the same time.
8.1 Diabetes mellitus 2006324 Effect of vitamin C on blood lipid and the aorta expression of heparin sulfate proteoglycan protein in streptozotocin-induced diabetic rats. LI Qiang-xiang , et al. The 1st Affiliated Hosp, Nanhua Univ, Henyang 421001. Loudi 417000. Chin J Atrero scler 2006;14(3):197-200. Objective: To observe the effect of vitamin C on blood lipid and aorta expression of heparin sulfate proteoglycan protein (HSPG) in streptozotocin-induced diabetic rats. Methods:Diabetic nephropathy rats were induced by intraperitoneal injection of STZ. Rats were allocated to normal control group, model group, and vitamin C group for 16 weeks. During and after the treatment, during and after the treatment, Its general state, blood suger ( BS), triglyceride (TG), total cholesterol (TC), low density lipoprotein ( LDLC), high density lipoprotein (HDLC), glycosylated hemoglobin (HbAlc) and glycosylated low density lipoprotein (G-LDL) Alteration of tissue morphology via HE staining was observed after the aorta was taken out from the rats executed by narcosis; heparin sulfate proteoglyean protein, were determined by immunohistochemistry. Results: (1) Diabetes mellitus and aorta lesion occurred in the four model groups. (2)Vitamin C had no effect on the blood gloucose levels, while they could improve the general state, improve the general state, decrease triglyceride (P<0.05), serum cholesterol (P<0.05), low density lipoprotein (P<0.05), glycosylated hemoglobin (P<0.05), and glycated low density lipoprotein (P<0.05), increase high density lipoprotein (P<0.05), The expression of HSPG in the kidney were significantly inhibited (P<0.05) at the same time.
