摘要
17.1 Schizophrenia 2006424 P50 auditory sensory gating in the medication-nave schizophrenics and normal healthy adults. WANG Hong-xing, et al. Dept Psych , Shanghaiond Med Univ Shanghai 200030. Chin J Psychiatry 2006;39(2):65-68. Objective: To investigate the variations of P50 auditory sensory gating (P50) in normal healthy adults and schizophrenics, and the relationship to the clinical symptoms. Methods:The study involved 58 medication-nve schizophrenia patients (SCh) and 108 normal controls (NC). P50 was measured by using the conditioning/testing paradigm presented with auditory double clicks stimuli. And the symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS). Results: ( 1 ) In normal controls, the differences in peak latencies at Cz, Fz, and Pz sites between S1-PS0 and S2-P50 were not significant, while the amplitudes of S1-P50 at Cz, Fz, and Pz sites were significantly higher than that of S2-P50 (P< 0.01 ). There were no significant differences in the P50 amplitude and latency, S2/S1 ratio between male and female NC groups.
17.1 Schizophrenia 2006424 P50 auditory sensory gating in the medication-nave schizophrenics and normal healthy adults. WANG Hong-xing, et al. Dept Psych , Shanghaiond Med Univ Shanghai 200030. Chin J Psychiatry 2006;39(2):65-68. Objective: To investigate the variations of P50 auditory sensory gating (P50) in normal healthy adults and schizophrenics, and the relationship to the clinical symptoms. Methods:The study involved 58 medication-nve schizophrenia patients (SCh) and 108 normal controls (NC). P50 was measured by using the conditioning/testing paradigm presented with auditory double clicks stimuli. And the symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS). Results: ( 1 ) In normal controls, the differences in peak latencies at Cz, Fz, and Pz sites between S1-PS0 and S2-P50 were not significant, while the amplitudes of S1-P50 at Cz, Fz, and Pz sites were significantly higher than that of S2-P50 (P< 0.01 ). There were no significant differences in the P50 amplitude and latency, S2/S1 ratio between male and female NC groups.
