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Severe gastrointestinal mucositis following high dose melphalan therapy for multiple myeloma

Severe gastrointestinal mucositis following high dose melphalan therapy for multiple myeloma
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摘要 Mucositis is a known complication following use of chemotherapy,but fatal mucositis is unusual and management of such cases may be challenging.Pathologically there is denudation of mucosa of gastrointestinal tract. Severe cases can develop ileus and even perforation of bowel wall.We report here a case of multiple myeloma who developed World Health Organization grade 4 gut mucositis following the use of high dose melphalan with the expulsion of"intestine-like"material. Mucositis is a known complication following use of chemotherapy, but fatal mucositis is unusual and management of such cases may be challenging. Pathologically there is denudation of mucosa of gastrointestinal tract. Severe cases can develop ileus and even perforation of bowel wall. We report here a case of multiple myeloma who developed World Health Organization grade 4 gut mucositis following the use of high dose melphalan with the expulsion of “intestine-like” material.
出处 《World Journal of Gastroenterology》 SCIE CAS 2013年第5期784-785,共2页 世界胃肠病学杂志(英文版)
关键词 GASTROINTESTINAL MUCOSITIS CHEMOTHERAPY Gastrointestinal mucositis Chemotherapy
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参考文献4

  • 1M Vera-Llonch,G Oster,CM Ford,J Lu,S Sonis.Oral mucositis and outcomes of autologous hematopoietic stem-cell transplantation following high-dose melphalan conditioning for multiple myeloma[].J Support Oncol.2007
  • 2Peterson DE,Bensadoun RJ,Roila F.Management of oraland gastrointestinal mucositis:ESMO Clinical Practice Guide- lines[].Annals of Oncology.2011
  • 3Krishna SG,Zhao W,Grazziutti ML,Sanathkumar N,Bar- logie B,Anaissie EJ.Incidence and risk factors for lower ali- mentary tract mucositis after 1529 courses of chemotherapy in a homogenous population of oncology patients:clinical and research implications[].Cancer.2011
  • 4Grazziutti ML,Dong L,Miceli MH,Krishna SG,Kiwan E,Syed N,Fassas A,van Rhee F,Klaus H,Barlogie B,Anaissie EJ.Oral mucositis in myeloma patients undergoing melpha- lan-based autologous stem cell transplantation:incidence, risk factors and a severity predictive model[].Bone Marrow Transplantation.2006

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