口服胺碘酮与静脉注射胺碘酮联合电复律转复持续性房颤的疗效比较

目的:比较口服胺碘酮与静脉注射胺碘酮联合电复律转复持续性心房颤动及维持窦性心律的疗效。方法:本组40例持续性房颤患者,分为口服胺碘酮组与静脉注射胺碘酮组,每组20例。口服用药组采用胺碘酮治疗,共600mg,分3次口服,连续7天,未转复者电复律以最低有效量维持窦律;静脉用药组采用胺碘酮150mg稀释后缓慢静脉注射治疗,后以1mg/min维持静滴胺碘酮,同时予以电复律,6小时后改为0.5mg/min,24-48小时后改为口服胺碘酮维持。结果:40例患者均转复为窦性心律,口服用药组与静脉用药组早期有效率分别为95%和80%。结论:胺碘酮联合电复律是治疗持续性房颤的有效方法,但口服用药的早期有效率优于静脉用药。

Objective:To evaluate the effectiveness of cardioversion and maintenance of sinus rhythm between two route of administration(oral amiodarone and intravenous amiodarone)in converting persistent atrial fibrillation.Methods :Forty patients with persistent atrial fibrillation,20 in each group.one group took oral amiodarone(200mg three times per day for7 days)before electrical cardioversion and sinus rhythm were maintained with amiodarone;the other group took intravenous amiodarone,150mg intravenous dilated slowly,then treated with electrical cardioversion and 1mg/min intravenous for 6 hours,then 0.5mg/min intravenous for 24-48 hours,then took oral amiodarone for maintainance.Results :Forty patients were converted to sinus rhythm.In the oral group, the maintenance rate of sinus rhythm was 95% at the end of 24-h follow-up.In the intravenous group,the maintenance rate of sinus rhythm was 80% at the end of 24-h follow-up.Conclusions :Amiodarone and electrical cardioversion may provide an effective therapy in converting persistent atrial fibrillation.Oral amiodarone have an advantage over intravenous amiodarone.