Cell traction force distribution and its implications in cell adhesion and migration

Cell-matrix interaction is the key for understanding the cell behaviors,especially the mechanosensitivity of cell adhesion,cell migration and differentiation,etc.Cells are constantly probing,pushing and pulling on the surrounding extracellular matrix.These cell-generated forces drive cell migration and tissue morphogenesis,and maintain the intrinsic mechanical tone of tissues.Therefore,knowledge of the spatial and temporal nature of these forces are essential to understanding when and where mechanical events come to play in both physiological and pathological settings.However,because of the complexity of cell geometry and insufficient

Cell-matrix interaction is the key for understanding the cell behaviors,especially the mechanosensitivity of cell adhesion,cell migration and differentiation,etc.Cells are constantly probing,pushing and pulling on the surrounding extracellular matrix.These cell-generated forces drive cell migration and tissue morphogenesis,and maintain the intrinsic mechanical tone of tissues.Therefore,knowledge of the spatial and temporal nature of these forces are essential to understanding when and where mechanical events come to play in both physiological and pathological settings.However,because of the complexity of cell geometry and insufficient resolution