摘要
Introduction A disintegrin and metalloproteinase 33（ADAM33）has been identified as a susceptibility gene for asthma<sup>[1]</sup>,In particular,ADAM33 mRNA is highly expressed in airway smooth muscle cells（ASMCs）and the level of soluble ADAM33（sADAM33）is known to inversely correlate with lung function such as bronchial hyperresponsiveness（BHR）<sup>[2]</sup>that is ultimately determined by the mechanical behaviors of ASMCs.However,few have studied how sADAM33would affect ASMC mechanics.Here,we manipulated the expression of SADAM33 in
Introduction A disintegrin and metalloproteinase 33（ADAM33）has been identified as a susceptibility gene for asthma[1],In particular,ADAM33 mRNA is highly expressed in airway smooth muscle cells（ASMCs）and the level of soluble ADAM33（sADAM33）is known to inversely correlate with lung function such as bronchial hyperresponsiveness（BHR）[2]that is ultimately determined by the mechanical behaviors of ASMCs.However,few have studied how sADAM33would affect ASMC mechanics.Here,we manipulated the expression of SADAM33 in cultured
出处
《医用生物力学》
EI
CAS
CSCD
北大核心
2013年第S1期107-108,共2页
Journal of Medical Biomechanics
基金
supported by National Natural Science Foundation of China(11172340)
Training Program for Hundreds of Distinguished Leading Scientists of Chongqing
Specialized Research Fund for the Doctoral Program of Higher Education of China(20120191120032)
