乳腺肿块超声造影定量分析研究

Quantitative analysis of contrast-enhanced ultrasound in breast lesions

目的探讨超声造影定量评估乳腺肿块的可行性和稳定性。方法通过重复分析良恶性乳腺肿块超声造影图像的定量参数,研究取3次数据的中位数、最相近两次数据的平均值及3次数据的平均值这3种方法所得数据与病理结果间的差异。结果 151个乳腺肿块中,3种数据处理方法显示良恶性肿块的峰值P值均为0.000,曲线下面积(AUC)的P值分别为0.002、0.004、0.004。选择评判标准时,中位数法以AUC<3.850时诊断恶性肿块的灵敏度80.7%、特异度为61.9%,三者均值法以峰值<25.000时诊断恶性肿块的灵敏度为79.8%、特异度为71.4%,为最佳选择。结论应用超声造影定量分析评估乳腺肿块可行,重复分析,取中位数或平均值的方法均可减少数据偏差。

Objective To explore the feasibility and stability of contrast-enhanced ultrasound in quantitative assessment of breast lesions. Methods By repeating analysis of the quantitative parameters of contrast-enhanced ultrasound in benign and malignant breast lesions, the median of three sets of data, the mean of two closest sets of data and the mean of three sets of data were compared. Results In 151 breast tumors, three methods showed that there were significant differences in peak(all P=0.000) and area under curve(AUC)(P=0.002, 0.004 and 0.004, respectively) between benign and malignant breast lesions.When median AUC <3.850 was selected asthreshold, the sensitivity of diagnosis of malignant breast cancer was 80.7%, and the specificity was 61.9%. When mean peak of three sets of data <25.000 was selected as threshold, the sensitivity was79.8%, and the specificity was 71.4%. They were the best choices. Conclusion It's feasible to use quantitative analysis of contrast-enhanced ultrasound to evaluate the breast lesions. The median or mean can reduce data bias.