中药治疗对阻塞性睡眠呼吸暂停综合征患者氧化应激的影响

Influence of Chinese medicinal herbs on oxidative stress in patients with obstructive sleep apnea syndrome

目的观察中药治疗阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)患者的临床疗效及血清氧化应激标志物水平的变化。方法 66例OSAS患者随机分成治疗组34例和对照组32例,治疗组根据中医辨证施治予中药(免煎颗粒)开水冲服,1日2次;对照组采用安慰剂(中药免煎颗粒类似)处理,疗程3个月,比较两组治疗前后睡眠呼吸指标差异及超氧化物歧化酶(SOD)、总抗氧化力(TAOC)、谷光甘肽过氧化物酶(GSH-PX)、丙二醛(MDA)水平的变化。结果治疗组呼吸暂停-低通气指数(AHI)、夜间最低血氧饱和度(LSPO2)、夜间末梢血氧饱和度低于90%的累计时间(T<90%)较治疗前均有改善,超氧化物歧化酶、总抗氧化力、谷光甘肽过氧化物酶较治疗前升高,血清丙二醛较治疗前下降,差异有统计学意义(P<0.05)。与对照组比较,差异有统计学意义(P<0.05)。对照组前后比较差异无统计学意义(P>0.05)。结论中药在改善阻塞性睡眠呼吸暂停综合征患者睡眠呼吸指标的同时可能具有抗氧化作用。

Objective To observe the influence of Chinese medicinal herbs on clinic feature and serum markers of oxidative stress in patients with obstructive sleep apnea syndrome .Methods 66 OSAS cases were enrolled and divided randomly into treatment group (n= 34) and control group(n=32) .Treatment group was given oral Chinese medicinal herbs for 3 months ,twice a day ,while control group was given oral placebo . Polysomnography was calculated ,serum superoxide dismutase (SOD) ,total antioxidation capability (T-AOC) ,glutathione peroxidase (GSH-PX) and malondialdehyde (MDA)were determined before and after treatment .Results Apnea-hyperpnoea index (AHI) ,lowest nocturnal oxygen sat-uration(LSPO2 ) ,total minutes of nocturnal oxygen saturation lower 90% (T<90% )of treatment groups were improved after treatment ;SOD ,T-AOC ,GSH-PX were increased while MDA was decreased significantly (P<0.05) .However ,there were no significant changes in control group after treatment(P>0.05) .Conclusion Chinese medicinal herbs not only can improve the index of sleep breath but also probably has anti-oxidation influence on patients with obstructive sleep apnea syndrome .