婴幼儿肺炎血清硫化氢和白细胞介素-6的相关性分析

Analysis the relationship of serum hydrogen sulfide and interleukin-6in children with pneumonia

目的探讨肺炎患儿血清H2S和白细胞介素-6(IL-6)水平相关性。方法分别用亚甲蓝法和双抗夹心酶联免疫法测定34例肺炎患儿(疾病组)和20例健康儿童(对照组)血清H2S和IL-6浓度。结果与正常对照组比较,疾病组血清H2S浓度显著降低,统计学有显著差异(P<0.001);疾病组血清IL-6显著升高,统计学有显著差异(P<0.001)。疾病组患儿血清H2S浓度与IL-6呈显著负相关(R=-0.47,P<0.01)。结论毛细支气管炎症患儿血清H2S水平降低与白细胞中性粒细胞和炎症因子增加有关,血清H2S可作为炎症的标志物。

Objective To understand the relationship of serum hydrogen sulfide (H2 S) and interleukin-6 (IL-6) in children with pneumonia . Methods We measured the levels of H2S and IL-6 in children with pneumonia (disease group) and 20 health child (control group) by using meth-ylene blue and two-step sandich ELISA technique ,respectively .Pearson's correlation was used to determine the relationship between serum H2S concentration and IL-6 concentration in children with pneumonia .Results Compared to control group ,the plasma H2 S concentration were signifi-cantly decreased and the plasma IL-6 concentration were significantly increased in children with pneumonia (P<0.001) .Furthermore ,the plasma H2S concentration was negatively correlated with the IL-6 (R=-0.47 ,P<0.01) concentration .Conclusion The plasma H2S levels decreased was correlated with the inflammatory cytokines in children with pneumonia ,The plasma H2S could be used as a marker of inflammation .