参麦注射液对脓毒血症临床疗效研究

Shenmai injection on of sepsis clinical efficacy study

目的了解参麦注射液对脓毒血症患者的疗效及对血清TNF-α、IL-6、C-RP的影响,探讨参麦注射液对脓毒症患者保护的作用机制。方法将50例脓毒症患者随机分为两组,对照组25例予以常规西医对症治疗,治疗组25例在对照组治疗的基础上加用参麦注射液进行治疗。观察两组疗效,同时两组患者分别在治疗第1天及第10天抽血检测TNF-α、IL-6、C-RP浓度。结果与对照组相比,治疗后治疗组有效率高于对照组(P<0.01);血TNF-α、IL-6、C-RP水平显著降低(P<0.05)。结论参麦注射液可降低血清促炎因子水平及病死率对脓毒症患者具有保护作用。

Objective:Understand efficacy of Shenmai injection on patients with sepsis and serum TNF-α,IL-6,C-RP,and to explore the protective mechanism Shenmai injection on patients with sepsis。 Methods:50 septic patients were randomly divided into two groups,25 cases are symptomatic treatment of conventional Western medicine,the treatment group,25 patients in the control group,the treatment on the basis of treatment plus Shenmai injection.Effects were observed,while the two groups of patients,respectively,in the first day of treatment and 10 days,blood testing TNF-α,IL-6,the concentration of C-RP.Results:Compared with the control group,effective after treatment in the treatment group than the control group(P<0.01),significant decrease in blood levels of TNF-α,IL-6,C-RP(P<0.05).Conclusion:Shenmai injection can reduce serum levels of proinflammatory cytokines and case-fatality rate for patients with sepsis have a protective effect.