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Properties of Scaffold Reinforcement for Tendon Tissue Engineering in vitro Degradation

Properties of Scaffold Reinforcement for Tendon Tissue Engineering in vitro Degradation
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摘要 Four kinds of braided yarns were produced with different proportions of polyglycolic acid( PGA) and polylactic acid( PLA)multifilaments( 2PGA /1PLA, 2PGA /2PLA, 3PGA /1PLA, and3PGA /2PLA). A novel artificial plain stitch scaffold reinforcement was manufactured by braiding technology and knitting technology respectively. Tendon scaffold reinforcements were investigated for 8weeks in phosphate buffered solution( PBS)( pH = 7. 4) at 37 ℃.The degradation was studied with regard to the mass loss,tensile properties,grams per square meter( g /m2),thickness,caliber,and porosity of scaffold reinforcements. The experimental showed that during the process of 8-week degradation,the mass losses of scaffold reinforcements were small in the first 3-week,but they increased rapidly after 3-week,and the speeds tended to be small gradually after 6-week; the tensile properties dropped rapidly in the first 2-week; the grams per square meter and thicknesses speeded down obviously between 3-week to 6-week. The caliber and porosity of scaffold reinforcements first decreased and then increased gradually. The porosity can reach more than 97%. Four kinds of braided yarns were produced with different proportions of polyglycolic acid( PGA) and polylactic acid( PLA)multifilaments( 2PGA /1PLA, 2PGA /2PLA, 3PGA /1PLA, and3PGA /2PLA). A novel artificial plain stitch scaffold reinforcement was manufactured by braiding technology and knitting technology respectively. Tendon scaffold reinforcements were investigated for 8weeks in phosphate buffered solution( PBS)( pH = 7. 4) at 37 ℃.The degradation was studied with regard to the mass loss,tensile properties,grams per square meter( g /m2),thickness,caliber,and porosity of scaffold reinforcements. The experimental showed that during the process of 8-week degradation,the mass losses of scaffold reinforcements were small in the first 3-week,but they increased rapidly after 3-week,and the speeds tended to be small gradually after 6-week; the tensile properties dropped rapidly in the first 2-week; the grams per square meter and thicknesses speeded down obviously between 3-week to 6-week. The caliber and porosity of scaffold reinforcements first decreased and then increased gradually. The porosity can reach more than 97%.
出处 《Journal of Donghua University(English Edition)》 EI CAS 2013年第5期352-355,共4页 东华大学学报(英文版)
基金 Hi-Tech Research and Development Program of China(863 program)(No.2012AA020507)
关键词 polyglycolic acid(PGA) polylactic acid(PLA) TENDON SCAFFOLD REINFORCEMENTS degradation in VITRO properties polyglycolic acid(PGA) polylactic acid(PLA) tendon scaffold reinforcements degradation in vitro properties
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