摘要
[目的]探讨大黄加芒硝对危重病患者胃肠功能保护和治疗作用。[方法]纳入研究的患者均满足消化功能障碍和慢性健康状况评分系统(APACHEⅡ)≥16分并排除有器质性胃肠疾病的患者。治疗组:用生大黄50 g,开水100 mL浸泡15 min至深褐色,经胃管缓慢鼻饲,每8 h 1次,外用芒硝100 g,双层敷料包裹,平敷于肚脐处,待纱布袋潮湿后及时更换,每日更换2~3次;对照组:枸橼酸莫沙必利片10 mg,鼻饲,每8 h 1次。观察两组腹胀缓解时间、开始排便时间、肠内营养开始时间及消化道出血的发生率。[结果]治疗组在腹胀缓解的时间,顺利开始给予肠内营养的时间及开始排便时间均短于对照组,P<0.05或P<0.01。消化道出血发生率,治疗组显著低于对照组。[结论]大黄加芒硝能明显保护危重病患者胃肠功能,减少消化道出血的发生率,明显改善患者的预后。
[Objective] To observe the protective and treatment effects of rhubarb combined with sodium sulfate in critical care patients with gastrointestinal dysfunction.[Methods] The enrolled patients in the study had digestive disorders and APACHE Ⅱ≥16 scores and the patients with organic gastrointestinal diseases were excluded.In treatment group: the 50 mg of crude rhubarb was inserted in 100 mL of water at 100 ℃ for 15 minutes till dark brown was found.After that the drug was infused into the treatment patients by stomach tube feeding slowly,3 times a day.At the same time 100 g of sodium sulfate in double dressing package was flatly masked on belly button,changed a time when the gauze bag became wet and changed 2~3 times a day.In control group: 10 mg of mosanpride tablets was given by nasal feeding,3 times a day.The time of abdominal distension relieving,time of beginning to defecate,time of starting enteral nutrition and the incidence of gastrointestinal bleeding were observed in both groups.[Results] In treatment group the time of abdominal distension relieving,the time of smoothly starting enteral nutrition and defecate time were shorter than that in control group(P<0.05 or P<0.01).Incidence of gastrointestinal bleeding in treatment group was also significantly lower than that in control group.[Conclusion] Rhubarb combined with sodium sulfate can significantly protect the patients with gastrointestinal dysfunction in critical care,reduce the incidence of gastrointestinal bleeding and ameliorate the prognosis of patients.
出处
《天津中医药》
CAS
2013年第3期145-147,共3页
Tianjin Journal of Traditional Chinese Medicine
关键词
大黄
芒硝
危重病患者
胃肠功能
rhubarb
sodium sulfate
critical care patient
gastrointestinal function