乌司他丁对重症肺炎患者心肌损伤保护作用的研究

Myocardial protection of Ulinastatin on severe pneumonia patients

目的观察乌司他丁对重症肺炎患者的心肌损伤的保护作用。方法选择125例重症肺炎伴有心肌损害患者,按治疗方法不同分为对照组(62例)和实验组(63例)。对照组采用常规治疗方法,实验组在常规治疗基础上加用乌司他丁20万U,2次/天,连用7天;分别于治疗前、治疗后第2天及治疗后第6天采静脉血测量心房利钠肽(BNP)、血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、肌钙蛋白Ⅰ(c Tn I),并与对照组进行对比,同时对两组患者治疗前、治疗后第2天及第6天心排量进行比较。结果所有患者血清BNP、CK、CK-MB、c Tn I含量较治疗前均明显下降,有统计学意义(P<0.05),乌司他丁组改善更明显;实验组患者的心排量(CO)较对照组改善明显,有统计学意义(P<0.05)。结论应用乌司他丁注射液,可减轻重症肺炎患者的心肌损害,改善患者心功能。

ObjectiveTo investigate the influence of ulinastatin on myocardial protection of severe pneumonia patients.Method 125 patients with severe pneumonia were divided into control group (62cases) and experimental group (63cases) based on the treatment. The patients who were in control group were treated conventionally, and the patients who were in experimental group received similar therapy plus intravenous injection of ulinastatin 200,000u, twice a day for 7 days; The venous blood sample was collected before treatment, 2 days, 6 days after treatment separately to measure the concentration of serum brain natriuretic peptide( BnP),creatine kinase (cK),creatine kinase-mB (cK-mB) and cardiac troponin i(cTn i) all the values were compared between the two groups and the cardiac output of the two groups were observedResult The concentration of serum BnP,cK,cK-mB,cTn i values which decreased dramatically after treatment is statistically significant(P<0.05),especially in the experimental group.The cardiac output of experimental group improved significantly compared with that of control group(P<0.05).Conclusion ulinastatin in combination with routine therapies can reduce myocardial damage and improve cardiac function of severe pneumonia patients.