泛素样蛋白D在肝癌中的表达及临床意义

The expression and clinical signiifcance of Ubiquitin D in hepatocellular carcinoma

目的：观察UBD蛋白在肝癌及其癌旁组织中的差异表达，探讨UBD对肝癌预后判断的指导意义。方法应用Realtime PCR和免疫组织化学染色等方法从基因水平和组织学水平对肝癌及癌旁组织进行UBD表达分析，并结合患者临床资料进行回顾性分析。结果通过基因水平和组织学水平检测发现UBD在肝癌中表达显著高于癌旁组织中的表达（P=0.001），进一步分析发现UBD表达与肝癌患者预后密切相关（χ2=3.955，P=0.047）。结论首次发现UBD在肝癌中高表达，且其表达水平影响肝癌患者的预后，是肝癌潜在的预后判断指标。

Objective To observe the differential expression of UBD in HCC cancer tissue and peri-tumor tissue, and to explore its director significance on prognostic judgment. Methods Realtime PCR and immunohistochemical staining methods were used to measure the expression level of UBD in HCC tissues and its adjacent tissues and further retrospective statistical methods were used to analyze HCC patient prognosis combined with the clinical pathological data . Results Observe from the level of transcript and histological showed UBD high expression in HCC than adjacent tissues (P=0.001), UBD in HCC is particularly increased, further analysis revealed that patients with high expression of UBD experience poor prognosis(χ2=3.955, P=0.047). Conclusion We found UBD is highly expressed in HCC, and its expression levels in HCC has influenced the patients’ prognosis and maybe acts as the prognosis biomarker and target for HCC patients.