丝裂霉素C与羟基喜树碱对膀胱癌术后化疗的有效性及安全性比较的Meta分析

Meta-analysis on the efficacy and safety of mitomycin C and hydroxycamptothecin in treatment with bladder cancer postoperative

目的比较在文献中运用丝裂霉素C与羟基喜树碱治疗膀胱癌术后的有效性及安全性。方法运用计算机检索Pubmed(1970/2014-07)、EMbase(1974/2014-07)、Cochrane图书馆(2014年第7期)、中国生物医学文献数据库(1978/2014-07)中关于丝裂霉素C和羟基喜树碱在治疗膀胱癌术后化疗的有效性及安全性的随机对照实验,将检索时限定为2000年1月~2014年7月。对检索到的论文进行客观的质量评价,应用Cochrane协作网提供的Rev Man 5.3软件系统进行Meta分析。结果 Meta分析显示:与丝裂霉素C比较,羟基喜树碱复发率较低(OR=1.89,95%CI:1.41~2.53,P<0.0001),差异有统计学意义;与丝裂霉素C比较,羟基喜树碱不良反应率较低(OR=1.96,95%CI:1.55~2.48,P<0.0001),差异有统计学意义。结论羟基喜树碱治疗膀胱癌术后的疗效优于丝裂霉素C,并且治疗不良反应率也低于丝裂霉素C。

Objective To compare the efficacy and safety of Mitomycin C and hydroxycamptothecin in treatment of bladder cancer postoperative. Methods Literetures of randomized controlled trials about the efficacy and safety of MMC and HCPT in treatment of bladder cancer postoperative from Pubmed( 1970 /2014-07),EMbase( 1974 /2014-07),Cochranelibrary( 2014,June),CKNI database( 1978 /2014-07) from January2000 to June 2014 were retrived by computer. The quality of retrieved papers were evaluated objectively using Rev Man 5. 3 software provided by the Cochrane Collaboration Meta analysis system. Results Meta analysis results shows that: compared with Mitomycin C,HCPT had high recurrence rates( OR =1.89,95%CI:1.41 ~2.53,P <0.0001),the difference was significant; compared with Mitomycin c,adverse reaction rate in HCPT group was low( OR = 1. 96,95% CI: 1. 55-2. 48,P < 0. 0001),the difference was statistically significant. Conclusion The efficacy and safety of MMC is better than that of HCPT in treatment of postoperative bladder cancer.