5-FU治疗中晚期大肠癌13个随机对照临床试验的Meta分析

Meta analysis of 13 randomized controlled clinical trials of 5-FU in treatment of middle-late colorectal cancer

目的评价在随机对照临床试验中运用5-氟尿嘧啶(5FU)治疗中晚期大肠癌的临床疗效。方法运用计算机检索中国期刊网数据库中关于5-FU治疗中晚期大肠癌疗效的随机对照试验,将检索时限定为2000年1月~2014年6月。对检索到的论文进行客观的质量评价,得到13篇文献应用Cochrane协作网提供的Rev Man 5.3软件系统进行Meta分析。结果 5-FU与奥沙利铂治疗中晚期大肠癌总有效率比较差异有统计学意义(OR=1.61,95%CI:1.18~2.19,P=0.003);2组不良反应发生率比较差异有统计学意义(OR=0.48,95%CI:0.31~0.75,P=0.001)。结论 5-FU治疗中晚期大肠癌的疗效优于常规药物奥沙利铂,对于药物的不良反应率并不增加。目前仍需要治疗中晚期大肠癌多中心、大样本的随机对照试验研究。

Objective To assess the clinical curative effect of 5-fluorouracil( 5-FU) in treatment of middle-late colorectal cancer in randomized controlled clinical trials. Methods Literatures with randomized controlled trials about 5-FU in treatment of middle-late stage colorectal cancer in China journal net database were retrieved by computer and the time was limited to January 2000 and June 2014. The quality of retrieved papers were evaluate objectively and 13 articles were gone though Meta analysis by Rev Cochrane Man 5. 3 software system. Results The difference of the total effective rate of 5-FU and oxaliplatin in treatment of middle-late colorectal cancer was significant( OR = 1. 61,95% CI: 1. 18 ~ 2. 19,P = 0. 003); The incidence of adverse reactions between two groups was diffferent,the difference was statistically significant( OR = 0. 48,95% CI: 0. 31 ~ 0. 75,P = 0. 001).Conclusion The curative effect of 5-FU in treatment of middle-late colorectal cancer is better than oxaliplatin,and the drug adverse reaction rate doesnt increase. Multicenter,randomized controlled trials of therapeutic method were needed to further study in treantment of middle-late colorectal cancer.