氨茶碱和多索茶碱治疗支气管哮喘的临床疗效比较

Clinical observation of aminophylline and doxofyline in the treatment of bronchial asthma

目的探讨氨茶碱与多索茶碱在治疗支气管哮喘过程中疗效以及不良反应发生率的比较。方法回顾性分析2010年10月~2013年10月于杭州市萧山区第三人民医院肺功能检查确诊的60例支气管哮喘患者的临床资料,按照治疗药物的不同分为氨茶碱组和多索茶碱组(n=30),分别采用氨茶碱和多索茶碱治疗,观察2组患者治疗后12h、24h、36h的临床总有效率、不良反应发生率以及治疗后36 h患者肺功能指标变化。结果多索茶碱组患者与氨茶碱组患者相比,FEV1/FVC改善比较明显,差异具有统计学意义(P=0.000);12 h、24 h以及36 h临床总有效率较氨茶碱组均显著升高,差异具有统计学意义(P<0.05);且12 h、24 h以及36 h临床不良反应发生率较氨茶碱组亦显著降低,差异有统计学意义(P<0.01)。结论 2组治疗方案中,多索茶碱治疗效果更好且不良反应发生率低;氨茶碱治疗效果尚可,但不良反应发生率较高,临床需要综合患者病情选择合适的治疗方案。

Objective To compare the efficacy and incidence of adverse reactions of aminophylline with doxofyline on bronchial asthma. Methods Retrospective study of sixty patients with confirmed bronchial asthma from October 2010 to October 2013 were carried out. According to different drugs they used,patients were divided into two groups,each group contained 30 patients. Patients in aminophylline group received aminophylline,while patients in another group received doxofyline. Incidence of adverse reactions,improvement in clinical symptom after treatment for 12 h,24h and 36 h and improvement in lung function after treatment for 36 h were studied and compared. Results Compared with the patients in the group treated with aminophylline,there was significant improvement in clinical symptom after treatment of doxofyline for 36h( P = 0. 000),and lung function after 12 h,24h,36h( P < 0. 05) and less incidence of adverse reactions after 12 h, 24 h, 36h( P < 0. 05) when patients were served with doxofyline. Conclusion Doxofyline is better for achieving improvement in clinical symptom and lung function than aminophylline and it causes less adverse reactions. Clinical result of aminophylline is general and it causes a lot of adverse reactions. So we need to choose an appropriate drug to treat bronchial asthma due to the condition of the patients.