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桥本甲状腺炎合并原发性甲状腺弥漫性大B细胞淋巴瘤四例并文献复习 被引量:2

Hashimoto's thyroiditis with primary thyroid diffuse large B-cell lymphoma: Report of 4 cases and review of literature
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摘要 原发性甲状腺恶性淋巴瘤在临床上较为少见,约占所有原发甲状腺肿瘤的1% ~5%、所有淋巴瘤的1% ~ 2.5%[1-3].其中弥漫性大B细胞淋巴瘤相对多见,但临床表现缺乏特异性,早期易漏诊误诊.近年来,由于诊断水平的不断提高,其报告例数略有上升,在临床上该疾病常合并桥本甲状腺炎,本研究收集了2007年至2011年4例桥本氏甲状腺炎合并弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma)患者,并复习了近15年来相关文献.这4例手术切除的肿瘤标本均经10%的中性福尔马林溶液固定,石蜡包埋,常规制片和HE染色.免疫组化标记采用Elivision plus二步法.所用抗体为CK、CD3、CD10、CD20、CD21、CD79a、Ki67、Kappa、Lambda等,均购自福州迈新生物技术有限公司.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2014年第4期-,共4页 Chinese Journal of Endocrinology and Metabolism
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