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EGFR及其信号途径与肿瘤放射敏感性

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摘要 表皮生长因子受体(epidermal growth factor receptor,EGFR)已被表明与放射耐受性有关.作为治疗靶基因,通过对EGFR的抑制可增加放射敏感性,提高放射治疗的效果,为肿瘤的综合治疗又提供了一条途径.本文分别阐述了EGFR表达水平与放射敏感性的关系,EGFR介导的信号转导途径在放射敏感性中的作用,以及在肿瘤中应用EGFR抑制剂增加放射敏感性及抑制剂增敏与EGFR表达的关系.
作者 杨一兵 杨春妮
机构地区 昆明医学院第一附属医院耳鼻咽喉科
出处 《国际耳鼻咽喉头颈外科杂志》 2008年第1期-,共4页 International Journal of Otolaryngology-Head and Neck Surgery
关键词 受体 表皮生长因子(Receptor Epidermal Growth Factor) 辐射耐受性(Radiation Tolerance) 肿瘤(Neoplasms)
分类号 R734.2 [医药卫生—肿瘤]
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参考文献20

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二级参考文献11

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国际耳鼻咽喉头颈外科杂志
2008年 第1期

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