肺癌药物治疗的疗效预测
Research of predicting the outcome of treatment for lung cancer
摘要
近年来,肺癌的药物治疗进展迅速,细胞毒药物更新换代,靶向药物层出不穷.大量的临床数据证实,肺癌的药物治疗存在个体化差异,而这种差异,主要和药物的基因组学相关,利用药物基因组学实行对肺癌的个体化治疗,已成为肺癌转化性研究的热点.文章讨论了与肺癌药物治疗敏感性有关的主要分子标志物.
出处
《肿瘤研究与临床》
CAS
2007年第7期-,共4页
Cancer Research and Clinic
参考文献38
-
1Rosell R,Cobo M,Isla D. Applications of genomics in NSCLC[J].Lung Cancer,2005,(z2):S33-S40.doi:10.1016/S0169-5002(05)81571-5.
-
2林莉,刘晓晴,宋三泰.肺癌常用化疗药物相关的抗药标志研究进展[J].现代肿瘤医学,2006,14(3):352-354. 被引量:5
-
3Gautam A,Bepler G. Suppression of lung tumor formation by the regulatory subunit of ribonucleotide reductase[J].Cancer Research,2006,(13):6497-6502.doi:10.1158/0008-5472.CAN-05-4462.
-
4Bepler G,Sharma S,Cantor A. RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer[J].Journal of Clinical Oncology,2004,(10):1878-1885.doi:10.1200/JCO.2004.12.002.
-
5Bepler G,Kusmartseva I,Sharma S. RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer[J].Journal of Clinical Oncology,2006,(29):4731-4737.doi:10.1200/JCO.2006.06.1101.
-
6Taron M,Rosell R,Felip E. BRCA1 mRNA expression levels as an indicator of chemoresistance in lung cancer[J].Hum Mol Genet Genet,2004,(20):2443-2449.
-
7Quinn JE,Kennedy RD,Mullan PB. BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis[J].CANCER RESEARCH,2003,(19):6221-6228.
-
8Csiki I,Yanagisawa K,Haruki N. Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer[J].Cancer Research,2006,(01):143-150.doi:10.1158/0008-5472.CAN-05-1357.
-
9Arnold NB,Ketterer K,Kleeff J. Thioredoxin is downstream of Smad 7 in a pathway that promotes growth and suppresses cisplatin-induced apoptosis in pancreatic cancer[J].Cancer Research,2004,(10):3599-3606.doi:10.1158/0008-5472.CAN-03-2999.
-
10Oda Y,Ohishi Y,Saito T. Nuclear expression of Y-box-binding protein-1 correlates with P-glycoprotein and topoisomerase Ⅱ alpha expression,and with poor prognosis in synovial sarcoma[J].Journal of Pathology,2003,(02):251-258.
二级参考文献14
-
1Rosell R.Predicting response to Paclitaxol/Carboplatin -based therapy in NSCLC[J].Seminars in oncology,2002,28(4suppl 14):37~44.
-
2Rosell R.Pharmacogenomic research and serum DNA analysis in the treatment of non-smsll cell lung cancer[J].Rev Oncologia,2001,38:60~71.
-
3Kumagai A,Dunphy WG.Purification and molecular cloning of Plx1,a Cdc25-regulatory Kinase from Xenopus egg extracts[J].Science,1996,273(6):1377~1380.
-
4Rosell R.Determinants of response and resistance of cytotoxics[J].Semin Oncol,2002,291 suppl(4):110~118.
-
5Hou SM,Ryk C,Kannio A,et al.Influence of common XPD and XRCC1 variant alleles on p53 mutations in lung tumors[J].Environ Mol Mutagen,2003,41(1):37~42.
-
6Hu Z,Wei Q,Wang X,et al.DNA repair gene XPD polymorphism and lung cancer risk:a meta-analysis[J].Lung Cancer,2004,46(1):1~10.
-
7HDavid J,Park,Stoehlmacher J,et al.A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum -based chemotherapy in patients with advanced colorectal cancer[J].Cancer Research,2001,15:8654~8658.
-
8Camps C,Sarries C,Roig B.Assessment of nucleotide excision repair XPD polymorphisms in the peripheral blood of gemcitabine/cisplatin-treated advanced non-small-cell lung cancer patients[J].Clin Lung Cancer,2003,4(4):237~241.
-
9Rosell R,Crino L,Danenberg K.Targeted therapy in combination with gemcitabine in non-small cell lung cancer[J].Semin Oncol,2003,30(4 Suppl 10):19~25.
-
10Rosell R,Taron M,Barnadas A,et al.Nucleotide excision repair pathways involved in Cisplatin resistance in non-small-cell lung cancer[J].Cancer Control,2003,10(4):297~305.
共引文献8
-
1张光林,王钢胜,冯会.厄洛替尼治疗EGFR状态未知晚期肺腺癌的疗效观察[J].山东医药,2013,53(45):13-15. 被引量:3
-
2梁伟军,胡成平.DNA切除修复交叉互补基因1、乳腺癌易感基因、核苷酸还原酶1与非小细胞肺癌[J].肿瘤研究与临床,2007,19(7).
-
3艾星浩,陆舜.表皮生长因子受体通路阻断治疗晚期非小细胞肺癌[J].肿瘤研究与临床,2008,20(5):289-294. 被引量:1
-
4陈玲,叶韵斌,蔡丹,佘志廉,郑雄伟,张艳萍,何小玲,陈强.福建省非小细胞肺癌患者EGFR基因突变分析[J].肿瘤研究与临床,2008,20(8):509-512. 被引量:2
-
5崔海兰,李佩文,贾立群.平肺口服液调节肺癌小鼠血清瘦素水平的实验研究[J].中日友好医院学报,2006,20(4):222-224. 被引量:3
-
6尤江莲,魏素菊.肺癌常用化疗药物抗药标志进展及个体化用药[J].实用肿瘤杂志,2008,23(1):82-86. 被引量:4
-
7汪丽,谢金龙.肺癌相关化疗药物的抗药标志研究进展[J].临床军医杂志,2009,37(6):1135-1137.
-
8黄文喜,符立梧,梁永钜,谢文锋,梁李新.肺癌药敏芯片的研究进展[J].中国卫生产业,2013,10(27):181-181.
-
1黄红艳,江泽飞.复发转移性乳腺癌分子靶向药物治疗进展[J].中华乳腺病杂志(电子版),2010,4(2):18-21. 被引量:6
-
2余军武,胡祥华,刘宁,孙效刚.眼眶肿瘤的精确放射治疗[J].立体定向和功能性神经外科杂志,2004,17(5):303-304. 被引量:1
-
3聂星明.脊柱结核18例的CT表现[J].山西医药杂志(下半月),2012,41(5):462-463.
-
4王晖,刘心.多发性骨髓瘤的发病机制及药物治疗进展[J].国际病理科学与临床杂志,2006,26(5):403-406. 被引量:6
-
5吴文成.垂体瘤的药物治疗进展[J].国外医学(内分泌学分册),1990,10(2):72-75.
-
6黄健(综述),王晓稼(审校).晚期乳腺癌分子靶向药物治疗进展[J].国际肿瘤学杂志,2008,35(3):189-192.
-
7罗思红.慢性髓细胞白血病的药物治疗进展[J].北方药学,2013,10(8):49-49.
-
8张庆利.化疗所致胃肠道反应的药物治疗进展[J].中国社区医师,2002,18(8):8-8.
-
9闫志华.乳腺癌的药物治疗进展[J].山西医药杂志,2007,36(8):720-722.
-
10黄镜.晚期食管癌的药物治疗进展[J].中国临床研究,2010,23(1):1-4. 被引量:7