罗格列酮对MGC803细胞小鼠肾囊膜下移植瘤生长的影响

A study on the effects of PPARγ ligand rosiglitazone in the growth of MGC803 cells transplanted into subrenal-capsule of mice

目的 探讨过氧化酶体增生物激活受体γ(PPARγ)配体罗格列酮对小鼠体内人类胃癌MGC803细胞移植瘤生长的影响.方法 建立人类胃癌MGC803细胞小鼠肾囊膜下移植瘤模型,通过解剖显微镜和HE染色观察50 mg/kg的罗格列酮连续灌胃5 d作用于荷瘤小鼠后对移植瘤生长的抑制作用.结果 50 mg/kg的罗格列酮能明显抑N4,鼠肾囊膜下移植瘤MGC803细胞增生、诱导肿瘤细胞凋亡而抑制移植瘤的生长,抑瘤率达62.9%.结论 PPARγ配体罗格列酮能抑制小鼠体内肾囊膜下MGC803细胞移植瘤生长.

Objective To investigate the inhibitory effects of PPARγ ligand rosiglitazone in vivo of mice which were transplanted the human gastric carcinoma cells line MGC803 into subrenal-capsule.Methods To establish kunming mouse tumor modles of MGC803 cells transplanted into subrenal-capsule and assay the inhibiting growth effects of 50 mg／kg rosiglitazone which were continuously poured into mice gastric for five days by the dissect microscope and HE stain.Results Rosiglitazone could inhibit the growth of MGC803 cells transplanted into subrenal-capsule of mice in vivo by inhibiting proliferation and inducting apoptosis,the tumor inhibitory rate was 62.9％.Conclusion PPARγ ligand rosiglitazone can inhibit the growth of MGC803 cells transplanted into subrenal-capsule of mice in vivo.