缺氧诱导因子-1与卵巢肿瘤

HIF-1 and ovarian tumor

缺氧诱导因子-1(HIF-1)是细胞在缺氧的环境下产生的具有转录活性的核蛋白,其能够使组织对缺氧产生适应性反应,并与包括卵巢肿瘤在内的肿瘤的血管生成、能量代谢、侵袭性转移和预后有关.深入研究HIF-1与卵巢肿瘤之间的关系.探讨其在卵巢肿瘤中的作用和表达机制,将可能为卵巢肿瘤的治疗提供一条新途径.

Hypoxia-inducible factor-alpha-1 (Hif-lalpha) is an active-transcription nucleoprotein produced in cellular hypoxia condition, and HIF-1 can bring tissues into adaptation reaction when the tissues are in state of hypoxis. Apart from that, the factor is involved in angiogenesis of ovarian tumor, energy metabolism, invasive metabasis of the tumor and prognosis. Therefore, a new treatment of ovarian tumor may rely on the thorough study of the relationship between HIF-1 and the tumor by investigating its expression and mechanism.