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霍奇金淋巴瘤转染mtrⅡ基因后增生细胞核抗原表达的意义 被引量：1

The expression of PCNA in Hodgkin lymphoma cells which were treated mtr Ⅱ gene
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摘要 目的 探讨增生细胞核抗原(PCNA)在转染mtrⅡ基因后的霍奇金淋巴瘤(HL)中的表达情况及其意义.方法 将mtrⅡ转染人类HL细胞株,采用免疫组织化学法检测转染前后PCNA表达情况.结果 未转染mtrⅡ基因的PCNA阳性率为46.1%,转染mtrⅡ基因后PCNA的阳性率为78.6%,二者差异具有统计学意义(P＜0.05).结论 mtrⅡ基因与HL细胞增生程度密切相关.
作者 王星 林雨冬 王明元 吴德柱 王煜 杜京丽
机构地区 莆田
出处 《白血病．淋巴瘤》 CAS 2008年第1期-,共2页 Journal of Leukemia & Lymphoma
基金 福建省自然科学基金
关键词 霍奇金淋巴瘤 增殖细胞核抗原 基因 mtrⅡ
分类号 R733 [医药卫生—肿瘤]
  • 相关文献

参考文献8

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二级参考文献9

  • 1Huang G,Yan Q,Wang Z,et al.Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease[J].lnt J Oncol,2002,21(1):31-36.
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  • 7Zu K,Bihani T,Lin A,et al.Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells[J].Oncogene,2006,25(4):546-554.
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共引文献1

同被引文献7

  • 1王星,林雨冬,王明元,师建国,吴德柱,王煜,杜京丽.转染mtrⅡ基因后霍奇金病细胞增殖活性改变[J].中国康复理论与实践,2007,13(5):430-431. 被引量：2
  • 2Huang G, Yah Q, Wang Z, et al. Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease. Int J Oncol, 2002, 21: 31-36.
  • 3J.萨姆布鲁克拉塞尔DW.分子克隆实验指南.黄培堂,王嘉玺,朱厚础,等译.3版.北京:科学出版社,2003:26:1731-1732.
  • 4Razzaque A, Jahan N, McWeeney D, et al. Localization and DNA sequence analysis of the transforming domain (mtrⅡ) of human cytomegalovirus. Proc Natl Acad Sci U S A, 1988, 85: 5709-5713.
  • 5Doniger J, Muralidhar S, Rosenthal LJ. Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate. Clin Microbiol Rev, 1999, 12: 367-382.
  • 6Jung JE, Kim TK, Lee JS, et al. Survivin inhibits anti-growth effect of p53 activated by aurora B. Biechem Biophys Res Commun, 2005, 336: 1164-1171.
  • 7吕蓉,陈江华.CD30的功能与应用[J].国外医学（移植与血液净化分册）,2004,2(2):40-42. 被引量：3

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白血病．淋巴瘤
2008年 第1期

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