期刊文献+

弥漫大B细胞淋巴瘤信号通路与耐药研究进展 被引量:6

Drug resistance research advances on the signal pathways of diffuse large B-cell lymphoma
原文传递
导出
摘要 临床上弥漫大B细胞淋巴瘤(DLBCL)难治的原因主要是肿瘤细胞对化疗药物产生耐药.研究表明NF-κB、PI3K/Akt、PKC、MAPK等信号传导通路介导了耐药的产生,通过对DLBCL信号通路的研究可以深化理解该病耐药的发生发展机制,进一步判断预后,并且为个体化治疗提供理论基础.
作者 袁晓露 孟丹
出处 《白血病.淋巴瘤》 CAS 2008年第1期-,共3页 Journal of Leukemia & Lymphoma
基金 宁波市科学技术局资助项目
  • 相关文献

参考文献17

  • 1Rosenwald A,Wright G,Chan WC. The use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma[J].New England Journal of Medicine,2002,(25):1937-1947.doi:10.1056/NEJMoa012914.
  • 2Fisher RI,Gaynor ER,Dahlberg S. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin lymphoma[J].New England Journal of Medicine,1993,(14):1002-1006.doi:10.1056/NEJM199304083281404.
  • 3Ohsawa M,Ikura Y,Fukushima H. Immunohistochemical expression of muhidrug resistance proteins as a predictor of poor response to chemotherapy and prognosis in patients with nodal diffuse large B-cell lymphoma[J].Oncology(Basel),2005,(4-6):422-431.
  • 4Jazirehi AR,Huerta-Yepez S,Cheng G. Rituximab(chimeric anti-CD20 monoclonal antibody)inhibits the constitutive nuclear factor-{kappa}B signaling pathway in non-Hodgkin's lymphoma B-cell lines:role in sensitization to chemotherapeutic drug-induced apoptosis[J].Cancer Research,2005,(01):264-276.
  • 5Lam LT,Davis RE,Pierce J. Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling[J].Clinical Cancer Research,2005,(01):28-40.
  • 6Uddin S,Hussain AR,Siraj AK. Role of phosphatidylinositol3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival[J].Blood,2006,(13):4178-4186.doi:10.1182/blood-2006-04-016907.
  • 7Barancik M,Bohacova V,Sedlak J. LY294002,a specific inhibitor of P13K/Akt kinase pathway,antagonizes P-glycoprotein-mediated multidrug resistance[J].European Journal of Pharmaceutical Sciences,2006,(05):426-434.doi:10.1016/j.ejps.2006.08.006.
  • 8Espinosa I,Bfiones J,Bordes R. Membrane PKC-beta 2protein expression predicts for poor response to chemotherapy and survival in patients with diffuse large B-cell lymphoma[J].Annals of Hematology,2006,(09):597-603.doi:10.1007/s00277-006-0144-y.
  • 9Li S,Phong M,Lahn M. Retrospective analysis of protein kinase C-beta(PKC-beta)expression in lymphoid malignancies and its association with survival in diffuse large B-cell lymphomas[J].Biology Direct,2007,(01):8.doi:10.1186/1745-6150-2-8.
  • 10Kurosu T,Takahashi Y,Fukuda T. p38 MAP kinase plays a role in G2 checkpoint activation and inhibits apoptosis of human B cell lymphoma cells treated with etoposide[J].Apoptosis:An International Journal on Programmed Cell Death,2005,(05):1111-1120.

同被引文献56

引证文献6

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部