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Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection 被引量：1

Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection
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摘要 AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC resection.METHODS: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P < 0.001 for all). CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis. AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC resection.METHODS: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient’s median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P &lt; 0.001 for all). CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis.
作者 HMC Shantha Kumara Elizabeth A Myers Sonali AC Herath Joon Ho Jang Linda Njoh Xiaohong Yan Daniel Kirchoff Vesna Cekic Martin Luchtefeld Richard L Whelan
机构地区 Division of Colon and Rectal Surgery Division of Colon and Rectal Surgery Icahn School of Medicine at-Mount Sinai Surgical Oncology
出处 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2014年第10期413-419,共7页 世界胃肠肿瘤学杂志（英文版）（电子版）
关键词 COLORECTAL cancer MONOCYTE chemotactic protein-1 MINIMALLY invasive COLORECTAL RESECTION angio-genesis Colorectal cancer Monocyte chemotactic protein-1 Minimally invasive colorectal resection angiogenesis
分类号 R735.34 [医药卫生—肿瘤]
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参考文献13

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同被引文献29

  • 1Douglas Hanahan,Robert A. Weinberg.Hallmarks of Cancer: The Next Generation[J]. Cell . 2011 (5)
  • 2Rebecca Siegel,Deepa Naishadham,Ahmedin Jemal.Cancer statistics, 2013[J]. CA: A Cancer Journal for Clinicians . 2013 (1)
  • 3Alberto Mantovani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica.Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes[J]. Trends in Immunology . 2002 (11)
  • 4Chun Geun Lee,Carla A. Da Silva,Charles S. Dela Cruz,Farida Ahangari,Bing Ma,Min-Jong Kang,Chuan-Hua He,Seyedtaghi Takyar,Jack A. Elias.Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury[J]. Annual Review of Physiology . 2011
  • 5Catherine S.M. Diefenbach,Zharna Shah,Alexia Iasonos,Richard R. Barakat,Douglas A. Levine,Carol Aghajanian,Paul Sabbatini,Martee L. Hensley,Jason Konner,William Tew,David Spriggs,Martin Fleisher,Howard Thaler,Jakob Dupont.??Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer(J)Gynecologic Oncology . 2006 (2)
  • 6F.P.K. Wu,K. Hoekman,S. Meijer,M.A. Cuesta.??VEGF and Endostatin Levels in Wound Fluid and Plasma after Breast Surgery(J)Angiogenesis . 2003 (4)
  • 7In Keun Choi,Yeul Hong Kim,Jun Suk Kim,Jae Hong Seo.??High serum YKL-40 is a poor prognostic marker in patients with advanced non-small cell lung cancer(J)Acta Oncologica . 2010 (6)
  • 8H M.C. Shantha Kumara,Daniel Feingold,Matthew Kalady,Nadav Dujovny,Anthony Senagore,Neil Hyman,Vesna Cekic,Richard L. Whelan.??Colorectal Resection is Associated With Persistent Proangiogenic Plasma Protein Changes: Postoperative Plasma Stimulates In Vitro Endothelial Cell Growth, Migration, and Invasion(J)Annals of Surgery . 2009 (6)
  • 9Joseph J Carter,Daniel L Feingold,Irena Kirman,Anthony Oh,Peer Wildbrett,Zishan Asi,Ryan Fowler,Emina Huang,Richard L Whelan.??Laparoscopic-assisted cecectomy is associated with decreased formation of postoperative pulmonary metastases compared with open cecectomy in a murine model(J)Surgery . 2003 (3)
  • 10Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia(J)Urologic Oncology: Seminars and Original Investigations . 2008 (1)

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World Journal of Gastrointestinal Oncology
2014年 第10期

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