Disruption of low-density lipoprotein receptor pathway induced by inflammation contributes to podocyte injury in diabetic nephropathy

Objective To investigate the effects of low density lipoprotein receptor(LDLr)pathway on podocyte injury in diabetic nephropathy(DN)under inflammatory stress.Methods Male db/db mice and db/m mice were randomly divided into four groups(8 mice in each group):db/m group(control),casein injected db/m group(db/m+casein),db/db group(db/db),and casein