肝癌肺癌患者射频消融治疗后细胞免疫功能变化

Changes in the cellular immune function in patients with liver or lung cancer after radiofrequency ablation therapy

目的:研究集束电极射频消融(radiofrequencyablation,RFA)治疗对肝癌、肺癌患者细胞免疫功能的影响。方法:采用流式细胞术检测23例肝癌及21例肺癌患者RFA术后外周血T淋巴细胞亚群的变化。结果:与RFA术前比较,肝癌、肺癌患者术后1dCD3+、CD4+、CD8+和CD4+/CD8+无明显变化;术后1周CD3+、CD4+、CD8+和CD4+/CD8+均升高,除CD8+外,其他3项指标升高差异均有统计学意义。结论:与RFA术前相比,肝癌、肺癌患者的细胞免疫功能在术后1d无明显变化,术后1周明显增强。

Objective To explore the effects of radiofrequency ablation (RFA) on the cellular immune function in patients with liver or lung cancer. Method T-lymphocyte subsets in peripheral blood from 23 patients with liver cancer and 21 with lung cancer were measured by flow cytometry after the RFA procedure. Results The levels of CD3+, CD4+, CD8+and CD4+/CD8+ratio on day 1 after the RFA therapy were similar to those detected before this therapy but they all increased one week later. There was a significant difference in CD3+, CD4+and CD4+/CD8+ratio one week after the procedure. Conclusion The cellular immune function of patients with liver or lung cancer does not have any significant changes on day 1 after the RFA procedure but it is obviously improved one week following the therapy.