益生菌对儿童与青少年功能性便秘治疗效果的Meta分析

Efficacy of probiotic supplementation for treatment of functional constipation in children and adolescents:Meta-analysis

目的评价益生菌对儿童与青少年功能性便秘治疗的有效性,为临床应用提供循证依据。方法通过计算机检索等途径,收集国内外文献,纳入与本研究主题相关的随机对照研究。使用Revman5.1软件对结局指标进行统计分析及描述。结果共纳入6个随机对照研究。Meta分析结果显示,益生菌对儿童与青少年功能性便秘无明显治疗效果。亚组分析显示,益生菌的应用对便秘患儿的各种临床症状,包括腹痛情况、大便频次、大便硬度、大便潴留及用泻药频次均无明显改善。结论 Meta分析结果提示益生菌的应用对儿童与青少年功能性便秘无明显治疗效果。

Objective To assess the efficacy of probiotic supplementation for treatment of functional constipation in children and adolescents, and provide evidence for clinical practice. Methods Relevant randomized controlled trials were collected by electronic searching for domestic and overseas literature. Revman 5.1 software was adopted for statistical analy sis and description of outcome parameters. Results Six randomized controlled trials were included. Meta-analysis revealed that probiotic supplementation had no significant therapeutic effect in overall participants with functional constipa-tion. Subgroup analysis demonstrated that probiotic supplementation did not significantly ameliorate symptoms (abdominal pain, stool frequency, stool hardness and fecal soiling) of participants with functional constipation. Conclusion Meta-analysis indicates that probiotic supplementation may not have therapeutic effect on functional constipation in children and adolescents.