用欣母沛治疗产后出血的用药时机选择分析

Carboprost Tromethamine Injection treatment of postpartum hemorrhage timing

目的 :探讨用欣母沛治疗产后出血的给药时机。方法 :将2012年3月至2013年12月我院收治的120例发生产后出血的产妇根据用药时机的不同分为观察组和对照组,为观察组产妇在娩出胎儿时使用欣母沛进行治疗,为对照组产妇在出血量超过400ml时使用欣母沛进行治疗,比较两组产妇的止血情况和应激情况。结果 :观察组产妇的止血时间为(23.8±5.2)min,出血量为(165.3±21.5)ml,药物用量为(1.03±0.13)支,发生产褥期感染、晚期再出血的几率为(1.67%、1.67%),肾上腺素指标为(152.3±21.1)ng/ml,去甲肾上腺素指标为(173.4±22.2)ng/ml,肾素指标为(2.9±0.5)pg/ml,血管紧张素Ⅱ指标为(35.3±5.9)pg/ml,与对照组患者相比差异显著(P<0.05),均有统计学意义。结论 :为已发生产后出血的产妇或可能发生产后出血的高危产妇在娩出胎儿后立即使用欣母沛进行治疗可减少其产后出血量,缩短其止血时间,减少其用药量,缓解其应激反应。

To study timing of Carboprost Tromethamine Injection treatment of postpartum hemorrhage. Methods :120 cases maternal with postpartum hemorrhage were divided into observation group and the control group , observation group in fetal childbirth given carboprost tromethamine injection, the control group in maternal blood loss exceeds 400 ml given carboprost tromethamine injection, bleeding and stress index between two groups were compared. Result:Observation group bleeding time (23.8±5.2)min, bleeding (165.3±21.5)ml, drug dosage(1.03±0.13), again late puerperal infection, bleeding rate (1.67%, 1.67%), E(152.3±21.1)ng/ml, NE(173.4±22.2)ng/ml, R(2.9±0.5)pg/ml, ATⅡ(35.3±5.9)pg/ml levels were lower than the control group (P < 0.05). Conclusion:after fetal childbirth immediately give carboprost tromethamine injection helps to control postpartum blood loss, shorten the bleeding time, reduce the dosage of drugs, reduce stress reaction.