摘要
目的 :观察用卡维地洛治疗慢性心功能不全的疗效及对患者血浆活性醛水平的影响。方法 :将我院收治的64例慢性心功能不全患者随机分为对照组和观察组,每组各32例患者。为两组患者进行常规的抗心衰治疗,为观察组患者加用卡维地洛进行治疗,在治疗3个月后观察两组患者的临床疗效和血浆活性醛水平的变化。结果 :在治疗3个月后,两组患者治疗的总有效率相比较,差异显著(Z=-1.962,P<0.05),有统计学意义。与对照组患者相比较,观察组患者的左室射血分数(LVEF)和左室短轴缩短率(LVFS)较高,左室舒张末期内径(LVEDD)较低,差异显著(P<0.05),有统计学意义。两组患者的血浆丙二醛(MAD)和4-羟基壬烯醛(4-HNE)水平与治疗前相比较明显降低,差异显著(P<0.05),有统计学意义。与对照组患者相比较,观察组患者血浆中醛类物质的水平降低得更明显,差异显著(P<0.05),有统计学差异。结论:用卡维地洛治疗慢性心功能不全可获得显著的疗效,其机制可能与此药可降低患者血浆中活性醛的水平有关。
To observe effects of carvedilol on the curative effect and plasma active aldehyde of the patients with chronic cardiac insufficiency.Methods: According to the inclusion criteria,64 patients with chronic cardiac insufficiency were randomly divided into the control group and the research group, each group had 32cases, two groups of patients were performed conventional heart failure treatment after hospital,the research group were given carvedilol on the basis of the control group.After 3 month, the curative effect and plasma active aldehyde of two groups were observed. Results: After 3 month’s treatment, the total effective rate of two groups was statistically significant (Z=-1.962,P≤0.05). Comparing after the treatment of control group, LVEF and LVFS value increased, LVEDD value decreased,the difference was statistically significant(P≤0.05). Comparing before the treatment, plasma active aldehyde of two groups lowered.After the treatment,plasma active aldehyde(MAD and 4-HNE) in the research groups lowered than in the control group,the difference was statistically significant(P≤0.05). Conclusion:Carvedilol on the patients with chronic cardiac insufficiency have great curative effect, the treatment mechanism is possibly related lowering active aldehyde in blood- plasma.
