基于嵌合抗原受体的肿瘤免疫治疗

Chimeric antigen receptor for immunotherapy of cancer

肿瘤可通过下调激发机体免疫系统必需成分的表达,或通过分泌免疫抑制因子等机制逃避机体的免疫监视和攻击,从而得以在体内生存和恶性增殖。利用基因工程技术修饰T细胞,设计一种可特异性识别肿瘤相关抗原的嵌合抗原受体,使其同时兼具细胞免疫治疗和抗体免疫治疗的优点,是近年来迅速发展的肿瘤过继免疫治疗方法。

Down-regulating the necessary component of immune system and suppressing pro-duction of immunosuppressive factors results in the tumor immune escape.Recently,the genetic modification of T cells with chimeric antigen receptors (CARs)was designed to solve the mechanism of escape immunosurveillance.The unique structure of CARs endows T cell tumor specific cytotoxici-ty and tumor antigen recognition ability.This adoptive antitumor immunotherapy develops rapidly and brings hope to the patients with tumors.