神经梅毒患者血清白细胞介素-4、干扰素-γ的变化及其临床意义

Changes of serum interleukin-4 and IFN-γ in patients with neurosyphilis and their clinical significance

目的探讨神经梅毒患者血清白细胞介素-4(IL-4)、干扰素-γ(IFN-γ)的变化及其临床意义。方法选取2007年1月~2013年10月期间我院诊治的神经梅毒患者34例(神经梅毒组)及非神经梅毒患者34例(非神经梅毒组),选取34例正常体检者为对照组,患者在入院后及治疗1个月后、体检者在体检结束未发现有异常疾病后抽血检测IL-4、IFN-γ。结果三组之间IL-4、IFN-γ浓度明显存在不同(P<0.05),神经梅毒组、非神经梅毒组IL-4、IFN-γ浓度高于对照组(P<0.05),神经梅毒组与非神经梅毒组IL-4、IFN-γ浓度比较差异无统计学意义(P>0.05),神经梅毒组患者在治疗后IL-4、IFN-γ浓度明显低于治疗前(P<0.05)。结论神经梅毒与非神经梅毒患者均存在IL-4、IFN-γ升高变化,神经梅毒与非神经梅毒患者之间IL-4、IFN-γ无明显差异,经过治疗IL-4、IFN-γ水平会明显下降。

Objective To investigate the changes of serum interleukin-4(IL-4) and interferon-γ(IFN-γ) in the patients with neurosyphilis and their clinical significance. Methods Thirty-four patients with neurosyphilis(neurosyphilis group) and 34 patients with non-neurosyphilis(non-neurosyphilis group) treated in our hospital from January 2007 to October 2013 were selected, and 34 normal health examinees were selected as the control group. The patients’ blood was drawn to examine the IL-4 and IFN-γafter admission, 1 month after treatment and when not discovering abnormal diseases at the end of health examination. Results The three groups were significantly different in the IL-4 and IFN-γ concentrations(P < 0.05); The neurosyphilis group and the non-neurosyphilis group had higher IL-4 and IFN-γ concentrations than the control group(P < 0.05); The neurosyphilis group and the non-neurosyphilis group were not different in the IL-4 and IFN-γ concentrations, with no statistical significance(P > 0.05); The IL-4 and IFN-γconcentrations of the neurosyphilis group after treatment were significantly lower than those before treatment(P<0.05). Conclusion Both the neurosyphilis group and the non-neurosyphilis group have elevated IL-4 and IFN-γconcentrations;The neurosyphilis group and the non-neurosyphilis group were not significantly different in the IL-4 and IFN-γ;The IL-4 and IFN-γlevels decrease significantly after treatment.