HLA匹配角膜缘干细胞联合羊膜移植修复翼状胬肉

Co-transplantation of HLA-matched limbal stem cells and amniotic membrane for treatment of pterygium

背景:HLA匹配的角膜缘干细胞联合羊膜移植治疗翼状胬肉是眼科医生治疗的新理念,该方法治疗后并发症少、康复快、复发率低,尤其是能减少移植排斥反应等已被广泛接受。目的:探讨HLA匹配的角膜缘干细胞联合羊膜移植治疗翼状胬肉疗效。方法:选取2013年3月1日至2014年4月30日行HLA匹配的角膜缘干细胞联合羊膜移植治疗的翼状胬肉患者47例(47眼)作为试验组;回顾性分析2010年3月1日至2012年12月1日采用单纯翼状胬肉切除方法治疗的翼状胬肉患者40例(47眼)作为对照组,对两组患者治愈和复发情况进行比较。结果与结论:试验组47例,全部顺利完成治疗,无并发症,其中1例切口感染,特殊对症治疗后均已好转出院,全部患者均无移植排斥反应。试验组治愈45眼,复发2眼,复发率为4.3%。对照组47眼中治愈32眼,复发15眼,复发率31.9%。结果表明HLA匹配的角膜缘干细胞联合羊膜移植治疗翼状胬肉并发症少、复发率低,是治疗翼状胬肉一种行之有效的方法。

BACKGROUND: Co-transplantation of HLA-matched limbal stem cells and amniotic membrane is a new concept for the treatment of pterygium, which is characterized as few complications, fast recovery, and low relapse rate.This treatment has been widely used because of reduced rejections.OBJECTIVE: To investigate the therapeutic effect of HLA-matched limbal stem cells and amniotic membrane co-transplantation in the treatment of pterygium.METHODS: Forty-seven patients with pterygium(47 eyes) who underwent the co-transplantation of HLA-matched limbal stem cells and amniotic membrane from March 1, 2013 to April 30, 2014 were enrolled as test group.Another 40 patients with pterygium(47 eyes) who received traditional surgical method acted as control group.Therapeutic effectiveness and relapse were compared between the two groups.RESULTS AND CONCLUSION: The 47 cases in the test group were successfully treated with no complications and rejections, and only one case suffered from incision infection but discharged from hospital after symptomatic treatment. After treatment, pterygium relapsed in 2 of 47 eyes in the test group and 15 of 47 eyes in the control group, and the relapse rates were 4.3% and 31.9%, respectively. Results from this study show that the co-transplantation of HLA-matched limbal stem cells and amniotic membrane for treatment of pterygium has fewer complications and lower relapse rate, which is an effective method for the treatment of pterygium.