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miR-200c与肿瘤进展关系的研究进展 被引量：3

The relatimship between miR-200c and the progression of tumor
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摘要 microRNA(miRNA)是内源性非编码单链小RNA,参与细胞增殖、凋亡与分化等多种重要生命活动的调控。近年来研究发现,miRNAs参与多种恶性肿瘤的演进,起抑癌基因或原癌基因的作用。miR-200c是上皮-间质转化(epithelial-mesenchymal,EMT)过程中的重要调节基因,除了在正常细胞的表型转换中起作用,还在多种类型癌细胞的表型转换中起调节作用,能促进或者抑制肿瘤的侵袭转移能力。此外,关于miR-200c的研究还涉及肿瘤的耐药性和凋亡抗性。研究证实,miR-200c能够促进或抑制肿瘤的侵袭转移,逆转肿瘤细胞的耐药性和凋亡抗性。本文主要对不同肿瘤中miR-200c对肿瘤进展的影响进行综述。
作者 谭国斌 邱明宁 陈合格 柳建军
机构地区 广东医学院泌尿外科研究室
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2015年第1期120-124,共5页 Chinese Journal of Cancer Biotherapy
基金 国家自然科学基金资助项目(No.81402118) 广东省自然科学基金资助项目(No.2012B031800221)~~
关键词 MIR-200C EMT 抗凋亡 耐药 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
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参考文献42

  • 1Cochrane Dawn R,Spoelstra Nicole S,Howe Erin N,Nordeen Steven K,Richer Jennifer K.MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents. Molecular Cancer . 2009
  • 2Sidong Huang,Michael H?lzel,Theo Knijnenburg,Andreas Schlicker,Paul Roepman,Ultan McDermott,Mathew Garnett,Wipawadee Grernrum,Chong Sun,Anirudh Prahallad,Floris H. Groenendijk,Lorenza Mittempergher,Wouter Nijkamp,Jacques Neefjes,Ramon Salazar,Peter ten Dijke,Hidetaka Uramoto,Fumihiro Tanaka,Roderick L. Beijersbergen,Lodewyk F.A. Wessels,René Bernards.MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling[J]. Cell . 2012 (5)
  • 3Matjaz Rokavec,Weilin Wu,Jun-Li Luo.IL6-Mediated Suppression of miR-200c Directs Constitutive Activation of Inflammatory Signaling Circuit Driving Transformation and Tumorigenesis[J]. Molecular Cell . 2012 (6)
  • 4Park Sun-Mi,Gaur Arti B,Lengyel Ernst,Peter Marcus E.The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes and Development . 2008
  • 5Derek C. Radisky.miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype. Breast Cancer Research and Treatment . 2011
  • 6Stefania Bortoluzzi,Marta Biasiolo,Andrea Bisognin.MicroRNA–offset RNAs (moRNAs): by-product spectators or functional players?[J]. Trends in Molecular Medicine . 2011 (9)
  • 7Gang Wang,Eddie Shu-Yin Chan,Bonnie Ching-Ha Kwan,Philip Kam-Tao Li,Sidney Kam-Hung Yip,Cheuk-Chun Szeto,Chi-Fai Ng.Expression of microRNAs in the Urine of Patients With Bladder Cancer[J]. Clinical Genitourinary Cancer . 2012 (2)
  • 8Ben Davidson,Claes G. Tropé,Reuven Reich.The clinical and diagnostic role of microRNAs in ovarian carcinoma[J]. Gynecologic Oncology . 2014 (3)
  • 9Yujuan Shan,Lanwei Zhang,Yongping Bao,Baolong Li,Canxia He,Mingming Gao,Xue Feng,Weili Xu,Xiaohong Zhang,Shuran Wang.Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells[J]. The Journal of Nutritional Biochemistry . 2013 (6)
  • 10Keun Hur,Yuji Toiyama,Masanobu Takahashi,Francesc Balaguer,Takeshi Nagasaka,Junichi Koike,Hiromichi Hemmi,Minoru Koi,C Richard Boland,Ajay Goel.MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis[J]. Gut . 2013 (9)

二级参考文献18

  • 1Amr M.GHALEB,Mandayam O.NANDAN,Sengthong CHANCHEVALAP,W.Brian DALTON,Irfan M.HISAMUDDIN,Vincent W.YANG.Krüppel-like factors 4 and 5:the yin and yang regulators of cellular proliferation[J].Cell Research,2005,15(2):92-96. 被引量：22
  • 2Ying SY, Chang DC, Lin SL. The microRNA (miRNA) : Over- view of the RNA genes that modulate gene function. Mol Biotecb- nol, 2008, 38: 257-268.
  • 3Calin GA, Liu CG, Sevignani C, et al. MicroRNA profiling re- veals distinct signatures in B cell chronic lymphocytic leukemias. Proe Natl Acad Sci U S A, 2004, 101 : 11755-11760.
  • 4Gottardo F, Liu CG, Fcrraein M, et al. Miero-RNA profiling in kidney and bladder cancers. Urol Oncol, 2007, 25 : 387-392.
  • 5Yanaihara N, Caplen N, Bowman E, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. CancerCell, 2006, 9: 189-198.
  • 6Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature, 2005, 435: 834-838.
  • 7Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microR- NAs in vivo with "antagomirs". Nature, 2005, 438: 685-689.
  • 8Fontana L, Fiori ME, Albini S, et al. Antagomir-17-5p abol_i- shes the growth of therapy-resistant ncuroblastoma through p21 and BIM. PLoS One, 2008, 3: e2236.
  • 9Gregory PA, Bracken CP, Bert AG, et al. MicroRNAs as regula- tors of epithelial-mesenchymal transition. Cell Cycle, 2008, 7 : 3112-3118.
  • 10Gregory PA, Bert AG, Paterson EL, et al. The miR-200 family and miR-205 regulate epithelial to meseuchymal transition by tar- geting ZEB1 and SIP1. Nat Cell Biol, 2008, 10: 593-601.

共引文献28

同被引文献24

引证文献3

二级引证文献10

中国肿瘤生物治疗杂志
2015年 第1期

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