摘要
microRNA(miRNA)对许多生物学过程具有微调作用,ATP结合盒转运体A1(ABCA1)是调节高密度脂蛋白(HDL)代谢和功能的关键蛋白。目前已发现多种miRNA可抑制ABCA1表达,进而抑制胆固醇流出,降低血清HDL水平。而沉默miRNA或抑制其表达则无法抑制胆固醇流出,血清HDL水平无改变。目前对miRNA调控ABCA1表达进行了大量研究,有望带来治疗技术的革新,在调节脂代谢和抗动脉粥样硬化领域具有广阔前景。
MicroRNA( miRNA) have the fine-tune effect to many biological processes,while ATP binding cassette transporter A1( ABCA1) is the key protein to regulate high density lipoprotein( HDL) metabolism and function. It has been found that a variety of miRNA can inhibit the expression of ABCA1,thereby inhibit the cholesterol efflux,decrease the serum HDL levels. Silencing or inhibiting miRNA expression can not suppress the cholesterol efflux,neither the serum HDL levels changed. Currently people make a lot of studies on miRNA regulating ABCA1 expression,so it is expected to bring evolutions to the treatment technology,and has broad prospects in the field of lipid-regulation and anti-atherosclerosis.
出处
《中国动脉硬化杂志》
CAS
北大核心
2015年第1期105-108,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目资助(81341025)
