新诊断2型糖尿病患者血浆中性粒细胞明胶酶相关脂笼蛋白与颈总动脉内膜中膜厚度的关系

The Relationship Between the Concentration of Plasma Lipocalin-2 and Common Carotid Artery Intima-medial Thickness in Newly Diagnosed Type 2 Diabetic Patients

目的探讨新诊断2型糖尿病患者血浆中性粒细胞明胶酶相关脂笼蛋白(LCN2)浓度与颈总动脉内膜中膜厚度的关系。方法共纳入166例年龄在35~70岁之间、病程在1年以内的新诊断2型糖尿病患者,同时选取同期的65例健康正常人作为对照。采用高分辨超声检测2型糖尿病患者颈总动脉内膜中膜厚度,用双抗体酶联免疫吸附法检测血浆LCN2浓度。结果校正年龄、性别之后,2型糖尿病组的血浆LCN2浓度高于正常对照组(P<0.05)。将2型糖尿病组按照血浆LCN2浓度三分位分组,高浓度LCN2组颈总动脉内膜中膜厚度高于低浓度LCN2组(P=0.026)。在校正多个因素后,血浆LCN2浓度与颈总动脉内膜中膜厚度呈正相关(r=0.197,P=0.007)。新诊断2型糖尿病患者的血浆LCN2浓度是其颈总动脉内膜中膜厚度增厚的相关因素之一。结论新诊断2型糖尿病患者血浆LCN2浓度高于正常人,其血浆LCN2浓度与颈总动脉内膜中膜厚度呈正相关关系。血浆LCN2浓度上升可能是新诊断2型糖尿病患者颈总动脉内膜中膜厚度增厚的危险因素之一。

Aim To investigate the relationship between the concentration of plasma lipocalin-2( LCN2) and common carotid artery intima-medial thickness( CCA-IMT) in newly diagnosed type 2 diabetic patients. Method 166 newly diagnosed type 2 diabetic patients( age 35 ~ 70,duration≤1 year) and 65 healthy people were recruited. CCAIMT was detected by high-resolution ultrasonography,plasma concentration of LCN2 was measured by enzyme-linked immunosorbent assay. Results Adjusting for age and sex,type 2 diabetics' plasma concentration of LCN2 was significantly higher than that in the healthy group( P < 0. 05). According to the three tilter of plasma concentration of LCN2,the highest concentration group's CCA-IMT was significantly higher than that in the lowest concentration group( P = 0. 026).In the multi-variables partial correlation analysis,adjusting for age,sex,body mass index( BMI),waist circumstance( WC),waist-to-hip ratio( WHR),diastolic blood pressure( DBP),hemoglobin A1c( Hb A1c),fasting insulin( FIN),HOMA-IR,triglyceride( TG),low density lipoprotein cholesterol( LDLC),the positive relationship between circulating LCN2 and CCA-IMT was observed( r = 0. 197,P = 0. 007). Multiply linear regression analysis demonstrated that circulating LCN2 contributed to elevation of CCA-IMT in newly diagnosed type 2 diabetic patients. Conclusion Plasma concentration of LCN2 was much higher in newly diagnosed type 2 diabetic patients than that in healthy people. Plasma concentration of LCN2 was positively correlated with CCA-IMT in newly diagnosed type 2 diabetic patients. Elevation of plasma concentration of LCN2 was probably one of the independent risk factors contribute to the elevation of CCA-IMT in newly diagnosed type 2 diabetic patients.