老年冠心病患者血浆Klotho水平测定的临床意义

Clinical Significance of Plasma Klotho Protein in Senile Patients with Coronary Artery Disease

目的探讨老年冠心病患者血浆Klotho蛋白测定的临床意义。方法随机选取60岁以上的老年住院患者,根据冠状动脉造影或冠状动脉CTA结果分为冠心病组138例(根据病变冠状动脉数目又分为单支病变组和多支病变组两个亚组)和对照组(140例),分别对各组进行血浆Klotho蛋白检测,并对冠心病组患者的冠状动脉狭窄程度与其血浆Klotho蛋白水平进行相关性分析。结果冠心病组患者血浆Klotho蛋白水平显著低于对照组,多支病变组患者血清Klotho蛋白水平低于单支病变组。冠心病组患者的冠状动脉狭窄程度与血浆Klotho蛋白水平呈负相关。结论血浆Klotho蛋白水平一定程度上可以反映冠状动脉狭窄程度,其可以作为评价冠状动脉狭窄程度的指标之一。

Aim To explore the relationship between coronary artery disease( CAD) and the level of plasma Klotho protein in the aged. Methods A total of 138 patients over 60 years old with CAD( experiment group) were enrolled,including 65 cases of single vessel lesion,73 cases of multivessels lesion. And a total of 140 controls above 60 years old without CAD were chosen. The levels of plasma Klotho protein were detected and compared between the two groups. The degree of coronary artery stenosis were assessed by Gensini scores. The correlation between coronary artery stenosis degree and the level of plasma Klotho protein was analyzed simultaneously. Results The level of plasma Klotho protein in experiment group was lower than that in control group. Moreover,the level of plasma Klotho protein in multivessels lesion group was lower than that in single vessel lesion group. The coronary artery stenosis degree was negatively correlated with the level of plasma Klotho protien. Conclusion The level of plasma Klotho protein may reflect the degree of coronary stenosis and could be used as an index to estimate the coronary artery stenosis degree.